Rationale and design of the OPTIMIZE trial: OPen label multicenter randomized trial comparing standard IMmunosuppression with tacrolimus and mycophenolate mofetil with a low exposure tacrolimus regimen In combination with everolimus in de novo renal transplantation in Elderly patients

被引：0
作者：
S. E. de Boer
J. S.F. Sanders
F. J. Bemelman
M. G.H. Betjes
J. G.M. Burgerhof
L. Hilbrands
D. Kuypers
B. C. van Munster
S. A. Nurmohamed
A. P.J. de Vries
A. D. van Zuilen
D. A. Hesselink
S. P. Berger
机构：
[1] University of Groningen,Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen
[2] Amsterdam Universal Medical Center,Department of Internal Medicine, Division of Nephrology
[3] Erasmus University Medical Center,Department of Internal Medicine, Division of Nephrology & Transplantation, Erasmus MC
[4] University Medical Center Groningen,Department of Epidemiology
[5] University of Groningen,Department of Internal Medicine, Division of Nephrology
[6] Radboud University Medical Center,Department of Nephrology and Renal Transplantation
[7] University Hospitals Leuven,Department of Internal Medicine, Divison of Geriatrics, University Medical Center Groningen
[8] University of Groningen,Department of Internal Medicine, Division of Nephrology; and Leiden Transplant Center
[9] Leiden University Medical Center,Department of Internal Medicine, Division of Nephrology
[10] Leiden University,undefined
[11] University Medical Center Utrecht,undefined
来源：
BMC Nephrology | / 22卷
关键词：
Elderly kidney transplant recipients; Reduced CNI exposure; mTOR inhibitor; Everolimus; (Health-related) quality of life; Patient-reported outcomes; Frailty; Immunosenescence; Randomized clinical trial; Multicenter trial;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 90 条
[1]  
Peters-Sengers H(2017)Stretching the limits of renal transplantation in elderly recipients of grafts from elderly deceased donors J Am Soc Nephrol 28 621-31
[2]  
Berger SP(2017)How does age affect the outcome of kidney transplantation in elderly recipients? Clin Transplant 31 e13036-89
[3]  
Heemskerk MBA(2010)The Combination of Donor and Recipient Age is Critical in Determining Host Immunoresponsiveness and Renal Transplant Outcome Trans Meet Am Surg Assoc 128 275-17
[4]  
Arashi D(2011)Premature aging of circulating T cells in patients with end-stage renal disease Kidney Int 80 208-43
[5]  
Van Der Heide JJH(2016)Lo of CD28 on peripheral T cells decreases the risk for early acute rejection after kidney transplantation PLoS One 11 e0150826-6
[6]  
Hemke AC(2001)Exponentially increased risk of infectious death in older renal transplant recipients Kidney Int 59 1539-8
[7]  
Neri F(1999)Immunological changes in the elderly Aging Clin Exp Res 11 281-7
[8]  
Furian L(2012)Kidney transplantation and the ageing immune system Nat Rev Nephrol 8 700-65
[9]  
Cavallin F(2009)Age-associated declines in immune system development and function: causes, consequences, and reversal Curr Opin Immunol 21 404-7
[10]  
Ravaioli M(2013)Immune cell dysfunction and inflammation in end-stage renal disease Nat Rev Nephrol 9 255-508
123456789