Disease-associated astrocytes in Alzheimer’s disease and aging

被引：0

作者：

Naomi Habib

Cristin McCabe

Sedi Medina

Miriam Varshavsky

Daniel Kitsberg

Raz Dvir-Szternfeld

Gilad Green

Danielle Dionne

Lan Nguyen

Jamie L. Marshall

Fei Chen

Feng Zhang

Tommy Kaplan

Aviv Regev

Michal Schwartz

机构：

[1] The Hebrew University of Jerusalem,Edmond & Lily Safra Center for Brain Sciences

[2] Broad Institute of MIT and Harvard,Klarman Cell Observatory

[3] The Weizmann Institute,Neurobiology Department

[4] Massachusetts Institute of Technology,Howard Hughes Medical Institute, McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences

[5] Massachusetts Institute of Technology,Department of Biological Engineering

[6] The Hebrew University of Jerusalem,School of Computer Science and Engineering

[7] Massachusetts Institute of Technology,Howard Hughes Medical Institute, Koch Institute of Integrative Cancer Research, Department of Biology

来源：

Nature Neuroscience | 2020年 / 23卷

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摘要：

The role of non-neuronal cells in Alzheimer’s disease progression has not been fully elucidated. Using single-nucleus RNA sequencing, we identified a population of disease-associated astrocytes in an Alzheimer’s disease mouse model. These disease-associated astrocytes appeared at early disease stages and increased in abundance with disease progression. We discovered that similar astrocytes appeared in aged wild-type mice and in aging human brains, suggesting their linkage to genetic and age-related factors.

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页码：701 / 706

页数：5

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