Disease-associated astrocytes in Alzheimer’s disease and aging

被引：0

作者：

Naomi Habib

Cristin McCabe

Sedi Medina

Miriam Varshavsky

Daniel Kitsberg

Raz Dvir-Szternfeld

Gilad Green

Danielle Dionne

Lan Nguyen

Jamie L. Marshall

Fei Chen

Feng Zhang

Tommy Kaplan

Aviv Regev

Michal Schwartz

机构：

[1] The Hebrew University of Jerusalem,Edmond & Lily Safra Center for Brain Sciences

[2] Broad Institute of MIT and Harvard,Klarman Cell Observatory

[3] The Weizmann Institute,Neurobiology Department

[4] Massachusetts Institute of Technology,Howard Hughes Medical Institute, McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences

[5] Massachusetts Institute of Technology,Department of Biological Engineering

[6] The Hebrew University of Jerusalem,School of Computer Science and Engineering

[7] Massachusetts Institute of Technology,Howard Hughes Medical Institute, Koch Institute of Integrative Cancer Research, Department of Biology

来源：

Nature Neuroscience | 2020年 / 23卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The role of non-neuronal cells in Alzheimer’s disease progression has not been fully elucidated. Using single-nucleus RNA sequencing, we identified a population of disease-associated astrocytes in an Alzheimer’s disease mouse model. These disease-associated astrocytes appeared at early disease stages and increased in abundance with disease progression. We discovered that similar astrocytes appeared in aged wild-type mice and in aging human brains, suggesting their linkage to genetic and age-related factors.

引用

页码：701 / 706

页数：5

共 50 条

[1] Disease-associated astrocytes in Alzheimer's disease and aging
Habib, Naomi
McCabe, Cristin
Medina, Sedi
Varshavsky, Miriam
Kitsberg, Daniel
Dvir-Szternfeld, Raz
Green, Gilad
Dionne, Danielle
Nguyen, Lan
Marshall, Jamie L.
Chen, Fei
Zhang, Feng
Kaplan, Tommy
Regev, Aviv
Schwartz, Michal
NATURE NEUROSCIENCE, 2020, 23 (06) : 701 - +
[2] Astrocytes in the aging brain and in Alzheimer's disease
Hol, E.
GLIA, 2015, 63 : E69 - E70
[3] ASTROCYTES IN PHYSIOLOGICAL AGING AND ALZHEIMER'S DISEASE
Rodriguez-Arellano, J. J.
Parpura, V.
Zorec, R.
Verkhratsky, A.
NEUROSCIENCE, 2016, 323 : 170 - 182
[4] Alteration of global protein SUMOylation in neurons and astrocytes in response to Alzheimer's disease-associated insults
Maruyama, Takuma
Wada, Harmony
Abe, Yoichiro
Niikura, Takako
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 500 (02) : 470 - 475
[5] Computational Screening and Exploration of Disease-Associated Genes in Alzheimer's Disease
Jamal, Salma
Goyal, Sukriti
Shanker, Asheesh
Grover, Abhinav
JOURNAL OF CELLULAR BIOCHEMISTRY, 2017, 118 (06) : 1471 - 1479
[6] Postmortem stability of Alzheimer's disease-associated proteins
Woltjer, Randall L.
Quinn, Joseph
Kaye, Jeffrey
NEUROLOGY, 2008, 70 (11) : A277 - A277
[7] Alzheimer's disease-associated disability:: An ICF approach
Muò, R
Schindler, A
Vernero, I
Schindler, O
Ferrario, E
Frisoni, GB
DISABILITY AND REHABILITATION, 2005, 27 (23) : 1405 - 1413
[8] Astrocytes in Alzheimer’s disease
Alexei Verkhratsky
Markel Olabarria
Harun N. Noristani
Chia-Yu Yeh
Jose Julio Rodriguez
Neurotherapeutics, 2010, 7 : 399 - 412
[9] Astrocytes in Alzheimer's Disease
Verkhratsky, Alexei
Olabarria, Markel
Noristani, Harun N.
Yeh, Chia-Yu
Julio Rodriguez, Jose
NEUROTHERAPEUTICS, 2010, 7 (04) : 399 - 412
[10] Reduced Disease-Associated Microglial Phenotype Is Associated with Diabetes-Associated Alzheimer's Disease
Peng, Xuemin
DIABETES, 2021, 70

← 1 2 3 4 5 →