Histone H3K9 methylation is dispensable for Caenorhabditis elegans development but suppresses RNA:DNA hybrid-associated repeat instability

被引：0

作者：

Peter Zeller

Jan Padeken

Robin van Schendel

Veronique Kalck

Marcel Tijsterman

Susan M Gasser

机构：

[1] Friedrich Miescher Institute for Biomedical Research,Department of Human Genetics

[2] Faculty of Natural Sciences,undefined

[3] University of Basel,undefined

[4] Leiden University Medical Center,undefined

来源：

Nature Genetics | 2016年 / 48卷

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D O I：

暂无

中图分类号：

学科分类号：

摘要：

Susan Gasser and colleagues find that methylation at histone H3 lysine 9 (H3K9me) is required for repression of simple repeats and transposons in Caenorhabditis elegans. Loss of H3K9me in worms leads to extensive accumulation of insertions and deletions at repeat elements, which correlate with R-loop formation and increased sensitivity to replication stress.

引用

页码：1385 / 1395

页数：10

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