Synthesis of Amides Based on Biologically Active (5Z,9Z)-Eicosa-5,9-dienoic Acid

被引：1

作者：

Makarova, E. Kh. ^{[1
]}

Makarov, A. A. ^{[1
]}

Dzhemilev, U. M. ^{[2
]}

D'yakonov, V. A. ^{[2
]}

机构：

[1] Russian Acad Sci, Ufa Fed Res Ctr, Inst Petrochem & Catalysis, Ufa 450075, Russia

[2] Russian Acad Sci, Zelinsky Inst Organ Chem, Moscow 119991, Russia

来源：

RUSSIAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 60卷 / 03期

关键词：

metal complex catalysis; Grignard reagents; cross-cyclomagnesiation; 1,2-dienes; Cp2TiCl2; fatty acid amides; TOPOISOMERASE-I; 11-PHENYLUNDECA-5Z; 9Z-DIENOIC ACID; STEREOSELECTIVE-SYNTHESIS; FATTY-ACIDS; ENDOCANNABINOIDS; ACTIVATION; ANALOGS;

D O I：

10.1134/S1070428024030102

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New amides of (5Z,9Z)-eicosa-5,9-dienoic acid, which is a highly active topoisomerase I/II inhibitor, were synthesized via Cp2TiCl2-catalyzed intermolecular cross-cyclomagnesiation of aliphatic and oxygen-containing 1,2-dienes as the key step.

引用

页码：437 / 441

页数：5

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