Physiology and role of irisin in glucose homeostasis

被引：0

作者：

Nikolaos Perakakis

Georgios A. Triantafyllou

José Manuel Fernández-Real

Joo Young Huh

Kyung Hee Park

Jochen Seufert

Christos S. Mantzoros

机构：

[1] Diabetes and Metabolism,Division of Endocrinology

[2] Beth Israel Deaconess Medical Center,Department of Endocrinology

[3] Harvard Medical School,Department of Family Medicine

[4] Hospital of Girona Doctor Josep Trueta,Division of Endocrinology and Diabetology, Department of Internal Medicine II

[5] University of Girona,undefined

[6] Centro de Investigación Biomédica en Red-Fisiopatología de la Obesidad y Nutrición (CIBERobn),undefined

[7] College of Pharmacy,undefined

[8] Chonnam National University,undefined

[9] Hallym University Sacred Heart Hospital,undefined

[10] Hallym University,undefined

[11] University Hospital of Freiburg,undefined

[12] Faculty of Medicine,undefined

[13] University of Freiburg,undefined

[14] Section of Endocrinology,undefined

[15] Boston VA Healthcare System,undefined

[16] Harvard Medical School,undefined

来源：

Nature Reviews Endocrinology | 2017年 / 13卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

Irisin is secreted primarily by muscle and in small amounts by adipose tissueIrisin improves glucose homeostasis, lipid profile and metabolic parameters in animals and acts on adipose tissue by inducing 'browning', as well as on muscle and liverInconsistencies in published data regarding the circulating levels of irisin highlight the need for accurate methods for irisin measurement and for improved study designLevels of irisin are increased in states of obesity and decreased in patients with type 2 diabetes mellitus (T2DM)Future studies should try to identify the irisin receptor and to investigate the effects of irisin on the endocrine pancreas and appetite centres in the brain; prospective clinical studies should investigate whether irisin is a predictive marker for insulin resistance, T2DM or the metabolic syndrome

引用

页码：324 / 337

页数：13

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