Distortion Product Otoacoustic Emission (DPOAE) as an Appropriate Tool in Assessment of Otoprotective Effects of Antioxidants in Noise-Induced Hearing Loss (NIHL)

被引：4
作者：
Doosti A. [1 ]
Lotfi Y. [1 ]
Moosavi A. [1 ]
Bakhshi E. [2 ]
Talasaz A.H. [3 ]
机构：
[1] Audiology Department, University of Social Welfare and Rehabilitation Sciences, P.O. Box 1985713834, Velenjak, Tehran
[2] Biostatistics Department, University of Social Welfare and Rehabilitation Sciences, Tehran
[3] Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran
来源：
Indian Journal of Otolaryngology and Head & Neck Surgery | 2014年 / 66卷 / 3期
关键词：
Antioxidants; Distortion product otoacoustic emission (DPOAE); Ginseng; N-Acetyl-cysteine (NAC); Noise-induced hearing loss (NIHL);
D O I：
10.1007/s12070-014-0721-7
中图分类号：
学科分类号：
摘要：
Distortion product otoacoustic emission (DPOAE) appears to be an objective sensitive test of cochlear function. The aim of this study was to investigate whether DPOAE is an appropriate tool for assessment of minute changes in cochlea due to usage of antioxidant material. 48 workers exposed to continuous noise in a textile factory were randomly assigned into three groups: (1) The Control group (n = 16) received no antioxidant drugs, (2) The N-acetyl-cysteine (NAC) group (n = 16) received oral antioxidant NAC (1200 mg/day), (3) The Ginseng group (n = 16) received oral antioxidant Ginseng (200 mg/day). All three groups had a follow-up period of 2 weeks. The cochlear changes were assessed using DPOAE test before starting the daily work shift on first and 15th day. The associations between groups and DPOAE amplitudes after 2 weeks were analyzed using linear regression analysis. Four separate models were fitted by side of ears and frequency. All models were adjusted for baseline amplitude. Reduced (better) amplitude at DPOAE test was found for NAC and Ginseng groups at high frequencies (4 and 6 kHz) in both ears after 2 weeks compared to control group. Moreover, NAC group showed better DPOAE amplitude than Ginseng group. In conclusion, DPOAE seems to be an appropriate tool in assessing minute changes in the cochlea after antioxidant drugs administration. © 2014, Association of Otolaryngologists of India.
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页码：325 / 329
页数：4
相关论文
共 30 条
[1]  
Rabinowitz P.M., Noise-induced hearing loss, American family physician, 61, 9, pp. 2749-2756, (2000)
[2]  
Henderson D., Bielefeld E.C., Harris K.C., Hu B.H., The role of oxidative stress in noise-induced hearing loss, Ear Hear, 27, 1, pp. 1-19, (2006)
[3]  
Prasher D., Sulkowski W., The role of otoacoustic emissions in screening and evaluation of noise damage, Int J Occup Med Environ Health, 12, 2, pp. 183-192, (1999)
[4]  
Henderson D., McFadden S.L., Liu C.C., Hight N., Zheng X.Y., The role of antioxidants in protection from impulse noise, Ann N Y Acad Sci, 28, 884, pp. 368-380, (1999)
[5]  
Fredelius L., Time sequence of degeneration pattern of the organ of corti after acoustic overstimulation. A transmission electron microscopy study, Acta Otolaryngol, 106, 5-6, pp. 373-385, (1988)
[6]  
Hamernik R.P., Henderson D., Impulse noise trauma. A study of histological susceptibility, Arch Otolaryngol, 99, 2, pp. 118-121, (1974)
[7]  
Muller J., Janssen T., Impact of occupational noise on pure-tone threshold and distortion product otoacoustic emissions after one workday, Hear Res, 246, 1-2, pp. 9-22, (2008)
[8]  
Attias J., Horovitz G., El-Hatib N., Nageris B., Detection and clinical diagnosis of noise-induced hearing loss by otoacoustic emissions, Noise Health, 3, 12, pp. 19-31, (2001)
[9]  
Hall A.J., Lutman M.E., Methods for early identification of noise-induced hearing loss, Audiology, 38, 5, pp. 277-280, (1999)
[10]  
Marshall L.L.M., Lapsley Miller J.A., Heller L.M., Distortion product otoacoustic emissions as a screening tool for noise-induced hearing loss, Noise Health, 3, pp. 43-60, (2001)
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