The Protective Effects of Terpinen-4-ol on LPS-Induced Acute Lung Injury via Activating PPAR-γ

被引：0
作者：
Jun Ning
Li Xu
Qing Zhao
Yu-yan Zhang
Chang-qing Shen
机构：
[1] Affiliated Hospital of Jining Medical University,Department of Paediatrics
来源：
Inflammation | 2018年 / 41卷
关键词：
LPS; lung injury; NF-κB; PPAR-γ; terpinen-4-ol;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Terpinen-4-ol, the major constituent of tea tree oil, has been reported to have anti-inflammatory effect. However, whether terpinen-4-ol could attenuate LPS-induced inflammation in lung tissues remains unclear. In the present study, we aimed to investigate the protective effects of terpinen-4-ol on LPS-induced acute lung injury (ALI) in mice. Terpinen-4-ol could inhibit LPS-induced ALI as confirmed by the decreased lung histopathological changes, MPO activity, and lung W/D ratio caused by terpinen-4-ol. The production of TNF-α and IL-1β in the BALF was suppressed by the treatment of terpinen-4-ol. Western blot analysis showed that terpinen-4-ol significantly attenuated LPS-induced phosphorylation of IκBα and NF-κB p65. Furthermore, the expression of PPAR-γ was dose-dependently upregulated by the treatment of terpinen-4-ol. In conclusion, the results of this study indicated that terpinen-4-ol inhibited LPS-induced ALI via activating PPAR-γ, which subsequently attenuated LPS-induced NF-κB activation and inflammatory response.
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页码：2012 / 2017
页数：5
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