Sodium-Coupled Transport of the Short Chain Fatty Acid Butyrate by SLC5A8 and Its Relevance to Colon Cancer

被引:0
作者
Muthusamy Thangaraju
Gail Cresci
Shiro Itagaki
John Mellinger
Darren D. Browning
Franklin G. Berger
Puttur D. Prasad
Vadivel Ganapathy
机构
[1] Medical College of Georgia,Department of Biochemistry and Molecular Biology
[2] Medical College of Georgia,Department of Surgery
[3] University of South Carolina,Department of Biological Sciences and Center for Colon Cancer Research
来源
Journal of Gastrointestinal Surgery | 2008年 / 12卷
关键词
Colon cancer; Tumor suppression; Histone deacetylation; DNA methylation; Dietary fiber; Commensal bacteria;
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页码:1773 / 1782
页数:9
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[1]  
Mortensen PB(1996)Short-chain fatty acids in the human colon: relation to gastrointestinal health and disease Scand J Gastroenterol 216 132-148
[2]  
Clausen MR(2001)Short-chain fatty acids and human colonic function: roles of resistant starch and nonstarch polysaccharides Physiol Rev 81 1031-1064
[3]  
Topping DL(2001)Histone deacetylases and cancer: causes and therapies Nat Rev Cancer 1 194-202
[4]  
Clifton PM(2005)Clinical development of histone deacetylase inhibitors as anticancer agents Annu Rev Pharmacol Toxicol 45 495-528
[5]  
Marks P(2004)Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na J Biol Chem 279 13293-13296
[6]  
Rifkind RA(2004)-coupled transporter for short-chain fatty acids J Biol Chem 279 44522-44532
[7]  
Richon VM(2004)Expression of slc5a8 in kidney and its role in Na J Physiol 557 719-731
[8]  
Breslow R(2006)-coupled transport of lactate Proc Natl Acad Sci U S A 103 7270-7275
[9]  
Miller T(2005)The human tumour suppressor gene SLC5A8 expresses a Na Biochem Soc Trans 33 237-240
[10]  
Kelly WK(2006)-monocarboxylate cotransporter Life Sci 78 2419-2425