Key factors in mTOR regulation

被引：0
作者：
Xiaochun Bai
Yu Jiang
机构：
[1] Southern Medical University,Department of Cell Biology, School of Basic Medical Sciences
[2] University of Pittsburgh School of Medicine,Department of Pharmacology and Chemical Biology
来源：
Cellular and Molecular Life Sciences | 2010年 / 67卷
关键词：
mTOR; TSC2; Rheb; FKBP38; PRAS40; hVps34; Rag GTPases; Phosphatidic acid;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Mammalian target of rapamycin (mTOR) is a protein serine/threonine kinase that controls a wide range of growth-related cellular processes. In the past several years, many factors have been identified that are involved in controlling mTOR activity. Those factors in turn are regulated by diverse signaling cascades responsive to changes in intracellular and environmental conditions. The molecular connections between mTOR and its regulators form a complex signaling network that governs cellular metabolism, growth and proliferation. In this review, we discuss some key factors in mTOR regulation and mechanisms by which these factors control mTOR activity.
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页码：239 / 253
页数：14
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