Efficacy and safety of oral sildenafil in children with Down syndrome and pulmonary hypertension

[1] Weijerman ME(2010)Prevalence of congenital heart defects and persistent pulmonary hypertension of the neonate with down syndrome Eur J Pediatr 169 1195-1199

[2] van Furth AM(2011)Management of pulmonary hypertension in down syndrome Eur J Pediatr 170 915-921

[3] van der Mooren MD(2015)Prevalence of congenital heart disease and pulmonary hypertension in Down's syndrome: an Echocardiographic study J Cardiovasc Ultrasound 23 72-77

[4] van Weissenbruch MM(2010)Changing demographics of pulmonary arterial hypertension in congenital heart disease Eur Respir Rev 19 308-313

[5] Rammeloo L(2006)Obstructive sleep apnea: should all children with down syndrome be tested? Arch Otolaryngol Head Neck Surg 132 432-436

[6] Broers CJ(2009)Obstructive sleep apnea in adults with down syndrome J Clin Sleep Med 5 317-323

[7] Gemke RJ(2011)Down syndrome patients with pulmonary hypertension have elevated plasma levels of asymmetric dimethylarginine Eur J Pediatr 170 859-863

[8] Hawkins A(2010)Mechanisms underlying early development of pulmonary vascular obstructive disease in down syndrome: an imbalance in biosynthesis of thromboxane A2 and prostacyclin Am J Med Genet A 152A 1919-1924

[9] Langton-Hewer S(2014)Clinical characteristics of pulmonary arterial hypertension associated with down syndrome Pediatr Int 56 297-303

[10] Henderson J(2009)On behalf of the 1131 study group. Oral sildenafil treatment in children with pulmonary arterial hypertension (PAH): results of a double-blind, placebo-controlled, dose-ranging study [abstract #164] Eur Resp J 34 S3-S4

[1] Weijerman ME(2010)Prevalence of congenital heart defects and persistent pulmonary hypertension of the neonate with down syndrome Eur J Pediatr 169 1195-1199

[2] van Furth AM(2011)Management of pulmonary hypertension in down syndrome Eur J Pediatr 170 915-921

[3] van der Mooren MD(2015)Prevalence of congenital heart disease and pulmonary hypertension in Down's syndrome: an Echocardiographic study J Cardiovasc Ultrasound 23 72-77

[4] van Weissenbruch MM(2010)Changing demographics of pulmonary arterial hypertension in congenital heart disease Eur Respir Rev 19 308-313

[5] Rammeloo L(2006)Obstructive sleep apnea: should all children with down syndrome be tested? Arch Otolaryngol Head Neck Surg 132 432-436

[6] Broers CJ(2009)Obstructive sleep apnea in adults with down syndrome J Clin Sleep Med 5 317-323

[7] Gemke RJ(2011)Down syndrome patients with pulmonary hypertension have elevated plasma levels of asymmetric dimethylarginine Eur J Pediatr 170 859-863

[8] Hawkins A(2010)Mechanisms underlying early development of pulmonary vascular obstructive disease in down syndrome: an imbalance in biosynthesis of thromboxane A2 and prostacyclin Am J Med Genet A 152A 1919-1924

[9] Langton-Hewer S(2014)Clinical characteristics of pulmonary arterial hypertension associated with down syndrome Pediatr Int 56 297-303

[10] Henderson J(2009)On behalf of the 1131 study group. Oral sildenafil treatment in children with pulmonary arterial hypertension (PAH): results of a double-blind, placebo-controlled, dose-ranging study [abstract #164] Eur Resp J 34 S3-S4