25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner

被引:0
作者
Man Ying Wong
Michael Lewis
James J. Doherty
Yang Shi
Anil G. Cashikar
Anna Amelianchik
Svitlana Tymchuk
Patrick M. Sullivan
Mingxing Qian
Douglas F. Covey
Gregory A. Petsko
David M. Holtzman
Steven M. Paul
Wenjie Luo
机构
[1] Weill Cornell Medicine,Appel Alzheimer’s Disease Research Institute, Feil Family Brain and Mind Research Institute
[2] Sage Therapeutics,Department of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer’s Disease Research Center
[3] Washington University School of Medicine,Department of Medicine, Duke University Medical Center
[4] Durham Veterans Health Administration Medical Center’s Geriatric Research,Departments of Developmental Biology, Anesthesiology, Taylor Family Institute for Innovative Psychiatric Research
[5] Education and Clinical Center,Departments of Neurology and Psychiatry, Hope Center for Neurological Disorders, Taylor Family Institute
[6] Washington University in St. Louis,undefined
[7] Washington University School of Medicine,undefined
来源
Journal of Neuroinflammation | / 17卷
关键词
Alzheimer’s disease; Microglia; Inflammation; Lipid metabolism; Apolipoprotein E; Interleukin-1β; Cholesterol 25-hydroxylase; Oxysterol; 25-Hydroxycholesterol; Lipopolysaccharide; Inflammasome;
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[1]  
Heneka MT(2015)Neuroinflammation in Alzheimer’s disease Lancet Neurol 14 388-405
[2]  
Carson MJ(2015)Innate immunity in Alzheimer’s disease Nat Immunol 16 229-236
[3]  
El Khoury J(2009)Toll-like receptors in Alzheimer’s disease Curr Top Microbiol Immunol 336 137-153
[4]  
Landreth GE(2015)beta-amyloid, microglia, and the inflammasome in Alzheimer’s disease Semin Immunopathol 37 607-611
[5]  
Brosseron F(2001)Gene expression profiling of amyloid beta peptide-stimulated human post-mortem brain microglia Neurobiol Aging 22 957-966
[6]  
Feinstein DL(2000)Beta-amyloid stimulation of inducible nitric-oxide synthase in astrocytes is interleukin-1beta- and tumor necrosis factor-alpha (TNFalpha)-dependent, and involves a TNFalpha receptor-associated factor- and NFkappaB-inducing kinase-dependent signaling mechanism J Biol Chem 275 7918-7924
[7]  
Heneka MT(2005)Inflammatory cytokine levels correlate with amyloid load in transgenic mouse models of Alzheimer’s disease J Neuroinflammation 2 9-823
[8]  
Golenbock DT(1995)Glial cytokines in Alzheimer’s disease: review and pathogenic implications Hum Pathol 26 816-7615
[9]  
Latz E(1989)Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease Proc Natl Acad Sci U S A 86 7611-20
[10]  
Landreth GE(1995)Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer’s and de novo Parkinson’s disease patients Neurosci Lett 202 17-708