Sex-dependent expression of neutrophil gelatinase-associated lipocalin in aortic stenosis

被引：0

作者：

Eva Jover

Lara Matilla

Ernesto Martín-Núñez

Mattie Garaikoetxea

Adela Navarro

Amaya Fernández-Celis

Alicia Gainza

Vanessa Arrieta

Amaia García-Peña

Virginia Álvarez

Rafael Sádaba

Frederic Jaisser

Natalia López-Andrés

机构：

[1] Hospital Universitario de Navarra (HUN),Cardiovascular Translational Research, Navarrabiomed (Miguel Servet Foundation), Instituto de Investigación Sanitaria de Navarra (IdiSNA)

[2] Universidad Pública de Navarra (UPNA),Centre de Recherche des Cordeliers, INSERM, UMRS 1138, Sorbonne Université, USPC

[3] Université Paris Descartes,undefined

[4] Université Paris Diderot,undefined

[5] Université Paris Cité,undefined

[6] Université de Lorraine,undefined

[7] INSERM,undefined

[8] Centre d’Investigations Cliniques-Plurithématique 1433,undefined

[9] UMR 1116,undefined

[10] CHRU de Nancy,undefined

[11] French-Clinical Research Infrastructure Network (F-CRIN) INI-CRCT (Cardiovascular and Renal Clinical Trialists),undefined

来源：

Biology of Sex Differences | / 13卷

关键词：

Aortic stenosis; Sex; Valve interstitial cells; NGAL; Valvular heart disease; Calcification;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

NGAL is expressed by inflammatory infiltrates and active VICs in the stenotic AV, being predominantly associated to inflammation, osteogenesis, and calcification.The levels of NGAL are higher in VICs and AVs from men than women’s and are associated with pathological features of AS.Intracellular NGAL is specifically down-regulated in calcifying male-derived VICs and is associated with inflammation, matrix remodelling and calcification.The pharmacological blockade of extracellular NGAL in calcifying male-derived VICs partly prevents from inflammation and matrix remodelling.

引用

共 338 条

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