RNA-binding proteins in neurological diseases

被引：0
作者：
HuaLin Zhou
Marie Mangelsdorf
JiangHong Liu
Li Zhu
Jane Y Wu
机构：
[1] Chinese Academy of Sciences,Institute of Biophysics
[2] The University of Queensland,Queensland Brain Institute
[3] Northwestern University Feinberg School of Medicine,Department of Neurology, Center for Genetic Medicine, Lurie Cancer Center
来源：
Science China Life Sciences | 2014年 / 57卷
关键词：
RNA-binding proteins; post-transcriptional regulation; neurological diseases;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Emerging studies support that RNA-binding proteins (RBPs) play critical roles in human biology and pathogenesis. RBPs are essential players in RNA processing and metabolism, including pre-mRNA splicing, polyadenylation, transport, surveillance, mRNA localization, mRNA stability control, translational control and editing of various types of RNAs. Aberrant expression of and mutations in RBP genes affect various steps of RNA processing, altering target gene function. RBPs have been associated with various diseases, including neurological diseases. Here, we mainly focus on selected RNA-binding proteins including Nova-1/Nova-2, HuR/HuB/HuC/HuD, TDP-43, Fus, Rbfox1/Rbfox2, QKI and FMRP, discussing their function and roles in human diseases.
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页码：432 / 444
页数：12
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