RNA-binding proteins in neurological diseases

被引：0
作者：
HuaLin Zhou
Marie Mangelsdorf
JiangHong Liu
Li Zhu
Jane Y Wu
机构：
[1] Chinese Academy of Sciences,Institute of Biophysics
[2] The University of Queensland,Queensland Brain Institute
[3] Northwestern University Feinberg School of Medicine,Department of Neurology, Center for Genetic Medicine, Lurie Cancer Center
来源：
Science China Life Sciences | 2014年 / 57卷
关键词：
RNA-binding proteins; post-transcriptional regulation; neurological diseases;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Emerging studies support that RNA-binding proteins (RBPs) play critical roles in human biology and pathogenesis. RBPs are essential players in RNA processing and metabolism, including pre-mRNA splicing, polyadenylation, transport, surveillance, mRNA localization, mRNA stability control, translational control and editing of various types of RNAs. Aberrant expression of and mutations in RBP genes affect various steps of RNA processing, altering target gene function. RBPs have been associated with various diseases, including neurological diseases. Here, we mainly focus on selected RNA-binding proteins including Nova-1/Nova-2, HuR/HuB/HuC/HuD, TDP-43, Fus, Rbfox1/Rbfox2, QKI and FMRP, discussing their function and roles in human diseases.
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页码：432 / 444
页数：12
相关论文
共 1307 条
[1]  
Keene JD(2007)RNA regulons: coordination of post-transcriptional events Nat Rev Genet 8 533-543
[2]  
Moore MJ(2005)From birth to death: the complex lives of eukaryotic mrnas Science 309 1514-1518
[3]  
Halbeisen RE(2008)Post-transcriptional gene regulation: from genome-wide studies to principles Cell Mol Life Sci 65 798-813
[4]  
Galgano A(2011)Construction, structure and dynamics of post-transcriptional regulatory network directed by RNA-binding proteins Adv Exp Med Biol 722 103-117
[5]  
Scherrer T(2007)RNA-binding proteins: modular design for efficient function Nat Rev Mol Cell Biol 8 479-490
[6]  
Gerber AP(2003)Cell-specific RNA-binding proteins in human disease Trends Cardiovasc Med 13 188-195
[7]  
Janga SC(2008)RNA-binding proteins in human genetic disease Trends Genet 24 416-425
[8]  
Mittal N(2013)Reflections on the history of pre-mRNA processing and highlights of current knowledge: a unified picture RNA 19 443-460
[9]  
Lunde BM(2012)Evolution of SR protein and hnRNP splicing regulatory factors Wiley Interdiscip Rev RNA 3 1-12
[10]  
Moore C(2013)Take the (RN)A-train: localization of mRNA to the endoplasmic reticulum Biochim Biophys Acta 1833 2519-2525
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