Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism

被引：0
作者：
Neelroop N. Parikshak
Vivek Swarup
T. Grant Belgard
Manuel Irimia
Gokul Ramaswami
Michael J. Gandal
Christopher Hartl
Virpi Leppa
Luis de la Torre Ubieta
Jerry Huang
Jennifer K. Lowe
Benjamin J. Blencowe
Steve Horvath
Daniel H. Geschwind
机构：
[1] Center for Autism Research and Treatment and Program in Neurobehavioral Genetics,Department of Neurology
[2] Semel Institute,Department of Molecular Genetics
[3] David Geffen School of Medicine,Department of Human Genetics
[4] University of California,Department of Biostatistics
[5] Los Angeles,undefined
[6] David Geffen School of Medicine,undefined
[7] University of California Los Angeles,undefined
[8] Centre for Genomic Regulation,undefined
[9] Barcelona Institute of Science and Technology (BIST),undefined
[10] Universitat Pompeu Fabra (UPF),undefined
[11] Donnelly Centre,undefined
[12] University of Toronto,undefined
[13] University of Toronto,undefined
[14] David Geffen School of Medicine,undefined
[15] University of California,undefined
[16] David Geffen School of Medicine,undefined
[17] University of California,undefined
来源：
Nature | 2016年 / 540卷
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摘要：
Gene expression analysis in brain tissue from individuals with and without autism spectrum disorder (ASD) suggests that the transcription factor SOX5 contributes to an ASD-associated reduction in transcriptional differences between brain areas and indicates that common transcriptomic changes occur in different forms of ASD.
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页码：423 / 427
页数：4
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