Clinical and pathological aspects of thymic epithelial tumors

被引：62

作者：

Okumura M. ^{[1
]}

Shiono H. ^{[1
]}

Minami M. ^{[1
]}

Inoue M. ^{[1
]}

Utsumi T. ^{[1
]}

Kadota Y. ^{[1
]}

Sawa Y. ^{[2
]}

机构：

[1] Department of General Thoracic Surgery (L5), Osaka University Graduate School of Medicine, Suita, Osaka 565-0871

[2] Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine, Osaka

来源：

General Thoracic and Cardiovascular Surgery | 2008年 / 56卷 / 1期

关键词：

Myasthenia gravis; Paraneoplastic autoimmunity; Thymic carcinoma; Thymoma; World Health Organization (WHO) histological classification;

D O I：

10.1007/s11748-007-0177-8

中图分类号：

学科分类号：

摘要：

A histological classification of thymic epithelial tumors was presented by the World Health Organization (WHO) in 1999 and again in 2004 following slight modifications, in which thymic epithelial tumors were categorized as thymomas and thymic carcinomas. Whereas thymoma is defined as an organotypic (thymuslike) tumor, thymic carcinoma is a malignant epithelial neoplasm with a morphology similar to that of malignant neoplasms arising from other organs. Herein, the recent progress in research of thymic epithelial tumors is reviewed with reference to the WHO histological classification system, with the focus on thymomas. Thymomas are classified into five types-A, AB, B1, B2, B3-according to the shape and atypia of their epithelial cells as well as the abundance of lymphocytes. The invasiveness, prognosis, and genetic imbalance of thymomas have been shown to be related to this classification system. Myasthenia gravis is frequently associated with types B1 and B2. The WHO histological classification of thymomas is not only useful for treatment but reflects their biological characteristics, including genetic alterations. Advances are expected in future studies of thymomas from the standpoint of their clinical, pathological, and biological aspects. © 2008 The Japanese Association for Thoracic Surgery.

引用

页码：10 / 16

页数：6

共 38 条

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