The Influence of Proinflammatory Factors on the Neuroprotective Efficiency of Multipotent Mesenchymal Stromal Cells in Traumatic Brain Injury

被引：0

作者：

T. I. Danilina

D. N. Silachev

I. B. Pevzner

M. V. Gulyaev

Yu. A. Pirogov

L. D. Zorova

E. Yu. Plotnikov

G. T. Sukhikh

D. B. Zorov

机构：

[1] M. V. Lomonosov Moscow State University,Faculty of Bioengineering and Bioinformatics

[2] M. V. Lomonosov Moscow State University,A. N. Belozersky Institute of Physicochemical Biology

[3] Ministry of Health of the Russian Federation,V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology

[4] M. V. Lomonosov Moscow State University,Laboratory of Magnetic Tomography and Spectroscopy, Faculty of Fundamental Medicine

[5] M. V. Lomonosov Moscow State University,International Laser Research Center

来源：

Bulletin of Experimental Biology and Medicine | 2017年 / 163卷

关键词：

mesenchymal stem cells; inflammation; neuroprotection; cytokines;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

We studied the neuroprotective potential of multipotent mesenchymal stromal cells in traumatic brain injury and the effect of inflammatory preconditioning on neuroprotective properties of stem cells under in vitro conditions. To this end, the effects of cell incubation with LPS or their co-culturing with leukocytes on production of cytokines IL-1α, IL-6, TNFα, and MMP-2 and MMP-9 by these cells were evaluated. Culturing under conditions simulating inflammation increased the production of all these factors by multipotent mesenchymal stromal cells. However, acquisition of the inflammatory phenotype by stromal cells did not reduce their therapeutic effectiveness in traumatic brain injury. Moreover, in some variants of inflammatory preconditioning, multipotent mesenchymal stromal cells exhibited more pronounced neuroprotective properties reducing the volume of brain lesion and promoting recovery of neurological functions after traumatic brain injury.

引用

页码：528 / 534

页数：6

共 50 条

[21] Multipotent mesenchymal stromal cells in articular diseases
Jorgensen, Christian
Djouad, Farida
Bouffi, Carine
Mrugala, Dominique
Noel, Daniele
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY, 2008, 22 (02): : 269 - 284
[22] Multipotent Mesenchymal Stromal Cells for Pulmonary Fibrosis?
Purdon, Stefanie
Patete, Carissa L.
Glassberg, Marilyn K.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2019, 357 (05): : 390 - 393
[23] Multipotent mesenchymal stromal cells for autoimmune diseases
Tyndall, Alan
TRANSFUSION MEDICINE AND HEMOTHERAPY, 2008, 35 (04) : 313 - 318
[24] Multipotent mesenchymal stromal cells and immune tolerance
Noel, Daniele
Djouad, Farida
Bouffi, Carine
Mrugala, Dominique
Jorgensen, Christian
LEUKEMIA & LYMPHOMA, 2007, 48 (07) : 1283 - 1289
[25] Interaction of multipotent mesenchymal stromal cells and lymphocytes
Kapranov, N.
Davydova, Y.
Galtseva, I.
Bakshinskayte, M.
Petinati, N.
Drize, N.
Kuzmina, L.
Parovichnikova, E.
Savchenko, V.
BONE MARROW TRANSPLANTATION, 2017, 52 : S171 - S171
[26] Current Status of Multipotent Mesenchymal Stromal Cells
Husain, Syed R.
Ohya, Yoshikazu
Toguchida, Junya
Puri, Raj K.
TISSUE ENGINEERING PART B-REVIEWS, 2014, 20 (03) : 189 - 189
[27] Mesenchymal stromal cell secretome as a therapeutic strategy for traumatic brain injury
Muhammad, Suleiman A.
BIOFACTORS, 2019, 45 (06) : 880 - 891
[28] Neural differentiation of canine mesenchymal stem cells/multipotent mesenchymal stromal cells
Sonja Prpar Mihevc
Vesna Kokondoska Grgich
Andreja Nataša Kopitar
Luka Mohorič
Gregor Majdič
BMC Veterinary Research, 16
[29] Neural differentiation of canine mesenchymal stem cells/multipotent mesenchymal stromal cells
Mihevc, Sonja Prpar
Grgich, Vesna Kokondoska
Kopitar, Andreja Natasa
Mohoric, Luka
Majdic, Gregor
BMC VETERINARY RESEARCH, 2020, 16 (01)
[30] Mesenchymal Stem Cells in the Treatment of Traumatic Brain Injury
Hasan, Anwarul
Deeb, George
Rahal, Rahaf
Atwi, Khairallah
Mondello, Stefania
Marei, Hany Elsayed
Gali, Amr
Sleiman, Eliana
FRONTIERS IN NEUROLOGY, 2017, 8

← 1 2 3 4 5 →