Inducible nitric oxide synthase (iNOS) expression may predict distant metastasis in human melanoma

被引：0
作者：
W Tschugguel
T Pustelnik
H Lass
M Mildner
W Weninger
C Schneeberger
B Jansen
E Tschachler
T Waldhör
J C Huber
H Pehamberger
机构：
[1] University of Vienna,Division of Gynaecological Endocrinology and Reproductive Medicine, Department of Gynaecology and Obstetrics
[2] School of Medicine,Division of General Dermatology
[3] Währinger Gürtel 18–20,Division of Immunology, Department of Dermatology
[4] University of Vienna,Department of Clinical Pharmacology;
[5] School of Medicine,undefined
[6] Währinger Gürtel 18–20,undefined
[7] Allergy and Infectious Diseases,undefined
[8] University of Vienna,undefined
[9] School of Medicine,undefined
[10] Währinger Gürtel 18–20,undefined
[11] University of Vienna,undefined
[12] School of Medicine,undefined
[13] Währinger Gürtel 18–20,undefined
[14] Institute for Tumour Biology and Cancer Research,undefined
[15] University of Vienna,undefined
[16] School of Medicine,undefined
[17] Währinger Gürtel 18–20,undefined
来源：
British Journal of Cancer | 1999年 / 79卷
关键词：
nitric oxide; human melanoma; metastasis;
D O I：
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中图分类号：
学科分类号：
摘要：
Expression of inducible nitric oxide synthase (iNOS) and its cellular localization was investigated in subcutaneous or lymph node metastases of human melanoma. Immunohistochemistry revealed that iNOS expression was limited to melanoma cells. In samples of patients without distant metastases, the number of iNOS+ tumour cells/total tumour cells was 55% ± 17% (n = 12) compared with 9% ± 8% when distant metastases of lung, liver or brain occurred within an observation period of 3 years (n = 10) (P < 0.001). Western blotting confirmed the expression of iNOS protein in select cases. Notably, iNOS is expressed in regional melanoma metastases and its expression is inversely related to the tumour’s metastatic potential. Thus, iNOS expression may have predictive value for the development of distant metastases of human melanoma.
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页码：1609 / 1612
页数：3
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