Newborn Screening for Cystic Fibrosis

被引：0
作者：
Jack K. Sharp
Michael J. Rock
机构：
[1] The State University of New York at Buffalo,Pediatric Pulmonology, Department of Pediatrics, The Women and Children’s Hospital of Buffalo
[2] Clinical Sciences Center,undefined
来源：
Clinical Reviews in Allergy & Immunology | 2008年 / 35卷
关键词：
Newborn screening; Cystic fibrosis; Immunoreactive trypsinogen (IRT); Cystic fibrosis transmembrane regulator (CFTR) mutation; Nutrition; Pulmonary disease;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Newborn screening (NBS) for cystic fibrosis (CF) has evolved considerably from its beginnings. We review the early history of NBS in the USA and the evolution of CF NBS from its conception in observational studies, to the development of mass-screening methodology in the 1970s, and to its early applications in the USA and other countries. We review the development of current CF NBS algorithms, particularly the development of those used in the Wisconsin randomized controlled trial, and discuss the comparative utility of different algorithms. We also discuss the identified nutritional and respiratory benefits of CF NBS, discuss treatment strategies for newborns identified with CF, and also discuss opportunities for slowing the progression of this disease.
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页码：107 / 115
页数：8
相关论文
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