Endoplasmic reticulum: Membrane contact sites

被引：0
作者：
Velikanov G.A. [1 ]
机构：
[1] Kazan Institute of Biochemistry and Biophysics, Kazan Research Center of the Russian Academy of Sciences, Kazan
来源：
Cell and Tissue Biology | 2013年 / 7卷 / 6期
关键词：
endoplasmic reticulum; functions; membrane contact sites;
D O I：
10.1134/S1990519X13060138
中图分类号：
学科分类号：
摘要：
This paper presents a review of modern data on the functional designation of membrane contact sites (MCSs) of endoplasmic reticulum. Problems of traffic of lipids and calcium in are discussed. It is to be emphasized that the function of MCSs is not yet clear, while the mechanism providing contact of two membranes (the problem of "anchors") remains poorly studied. Data are discussed that testify in favor of MCSs being able to participate both in selective traffic of lipids and in free diffusion of any small molecule (apparently, up to 1.5 kDa) and ions between cell compartments that are in contact. © 2013 Pleiades Publishing, Ltd.
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页码：504 / 511
页数：7
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