Comparison of the Rates of Disintegration, Gastric Emptying, and Drug Absorption Following Administration of a New and a Conventional Paracetamol Formulation, Using γ Scintigraphy

[1] Prescott L. F.(2000)Paracetamol: past, present, and future Am. J. Ther. 7 143-147

[2] Heading R.(1973)The dependence of paracetamol absorption on the rate of gastric emptying Br. J. Pharmacol. 47 415-421

[3] Nimmo J.(1978)Kinetics of acetaminophen absorption and gastric emptying in man Clin. Pharmacol. Ther. 24 420-431

[4] Prescott L.(1998)Intraindividual variability of paracetamol absorption kinetics after a semi-solid meal in healthy volunteers Br. J. Clin. Pharmacol. 53 355-359

[5] Tothill P.(2002)A new rapidly absorbed paracetamol tablet containing sodium bicarbonate. I. A four way crossover study to compare the concentration–time profile of paracetamol from the new paracetamol/sodium bicarbonate tablet and a conventional paracetamol tablet in fed and fasted volunteers Drug Dev. Ind. Pharm. 28 523-531

[6] Clements J. A.(2000)A five way crossover human volunteer study to compare the pharmacokinetics of paracetamol following oral administration of two commercially available paracetamol tablets and three development tablets containing paracetamol in combination with sodium bicarbonate or calcium carbonate Eur. J. Pharm. Biopharm. 49 225-229

[7] Heading R. C.(2002)A new rapidly absorbed paracetamol tablet containing sodium bicarbonate. II. Dissolution studies and Drug Dev. Ind. Pharm. 28 533-543

[8] Nimmo W. S.(1960) correlation J. Physiol. 154 254-269

[9] Prescott L. F.(1996)The osmotic effects of some simple molecules and ions on gastric emptying Pharm. Tech. 20 64-74

[10] Paintaud G.(1981)Mathematical comparison of curves with an emphasis on Gastroenterology 80 1497-1500

[1] Prescott L. F.(2000)Paracetamol: past, present, and future Am. J. Ther. 7 143-147

[2] Heading R.(1973)The dependence of paracetamol absorption on the rate of gastric emptying Br. J. Pharmacol. 47 415-421

[3] Nimmo J.(1978)Kinetics of acetaminophen absorption and gastric emptying in man Clin. Pharmacol. Ther. 24 420-431

[4] Prescott L.(1998)Intraindividual variability of paracetamol absorption kinetics after a semi-solid meal in healthy volunteers Br. J. Clin. Pharmacol. 53 355-359

[5] Tothill P.(2002)A new rapidly absorbed paracetamol tablet containing sodium bicarbonate. I. A four way crossover study to compare the concentration–time profile of paracetamol from the new paracetamol/sodium bicarbonate tablet and a conventional paracetamol tablet in fed and fasted volunteers Drug Dev. Ind. Pharm. 28 523-531

[6] Clements J. A.(2000)A five way crossover human volunteer study to compare the pharmacokinetics of paracetamol following oral administration of two commercially available paracetamol tablets and three development tablets containing paracetamol in combination with sodium bicarbonate or calcium carbonate Eur. J. Pharm. Biopharm. 49 225-229

[7] Heading R. C.(2002)A new rapidly absorbed paracetamol tablet containing sodium bicarbonate. II. Dissolution studies and Drug Dev. Ind. Pharm. 28 533-543

[8] Nimmo W. S.(1960) correlation J. Physiol. 154 254-269

[9] Prescott L. F.(1996)The osmotic effects of some simple molecules and ions on gastric emptying Pharm. Tech. 20 64-74

[10] Paintaud G.(1981)Mathematical comparison of curves with an emphasis on Gastroenterology 80 1497-1500