Metabolomics of Type 1 and Type 2 Diabetes: Insights into Risk Prediction and Mechanisms

[11] Eckel RH(2010)Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events Circ Cardiovasc Genet 3 207-1989

[12] Groop L(2013)A diabetes-predictive amino acid score and future cardiovascular disease Eur Heart J 34 1982-583

[13] Newgard CB(2019)Branched-chain amino acids in disease Science. 363 582-1177

[14] An J(2020)Branched-chain amino acids exacerbate obesity-related hepatic glucose and lipid metabolic disorders via attenuating Akt2 signaling Diabetes. 69 1164-93 e7

[15] Bain JR(2018)The BCKDH kinase and phosphatase integrate BCAA and lipid metabolism via regulation of ATP-citrate lyase Cell Metab 27 1281-56

[16] Muehlbauer MJ(2019)Risk of diabetes associated with fatty acids in the de novo lipogenesis pathway is independent of insulin sensitivity and response: the Insulin Resistance Atherosclerosis Study (IRAS) BMJ Open Diabetes Res Care 7 e000691-643

[17] Stevens RD(2016)Genetic predisposition to an impaired metabolism of the branched-chain amino acids and risk of type 2 diabetes: a Mendelian randomisation analysis PLoS Med 13 e1002179-1924

[18] Lien LF(2009)Metabolic profiling of the response to an oral glucose tolerance test detects subtle metabolic changes PLoS One 4 e4525-476

[19] Cheng S(2008)Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance Cell Metab 7 45-2226

[20] Rhee EP(2019)Association of dimethylguanidino valeric acid with partial resistance to metabolic health benefits of regular exercise JAMA Cardiol 4 636-816

[11] Eckel RH(2010)Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events Circ Cardiovasc Genet 3 207-1989

[12] Groop L(2013)A diabetes-predictive amino acid score and future cardiovascular disease Eur Heart J 34 1982-583

[13] Newgard CB(2019)Branched-chain amino acids in disease Science. 363 582-1177

[14] An J(2020)Branched-chain amino acids exacerbate obesity-related hepatic glucose and lipid metabolic disorders via attenuating Akt2 signaling Diabetes. 69 1164-93 e7

[15] Bain JR(2018)The BCKDH kinase and phosphatase integrate BCAA and lipid metabolism via regulation of ATP-citrate lyase Cell Metab 27 1281-56

[16] Muehlbauer MJ(2019)Risk of diabetes associated with fatty acids in the de novo lipogenesis pathway is independent of insulin sensitivity and response: the Insulin Resistance Atherosclerosis Study (IRAS) BMJ Open Diabetes Res Care 7 e000691-643

[17] Stevens RD(2016)Genetic predisposition to an impaired metabolism of the branched-chain amino acids and risk of type 2 diabetes: a Mendelian randomisation analysis PLoS Med 13 e1002179-1924

[18] Lien LF(2009)Metabolic profiling of the response to an oral glucose tolerance test detects subtle metabolic changes PLoS One 4 e4525-476

[19] Cheng S(2008)Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance Cell Metab 7 45-2226

[20] Rhee EP(2019)Association of dimethylguanidino valeric acid with partial resistance to metabolic health benefits of regular exercise JAMA Cardiol 4 636-816