Metformin mediated reversal of epithelial to mesenchymal transition is triggered by epigenetic changes in E-cadherin promoter

[1] Hawley S(2002)The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism Diabetes 51 2420-2425

[2] Gadalla AE(2009)New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes Diabetes Care 32 1620-1625

[3] Olsen GS(2007)Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells Cancer Res 67 10804-10812

[4] Grahame Hardie D(2015)A novel dual AMPK activator/mTOR inhibitor inhibits thyroid cancer cell growth J Clin Endocrinol Metab 100 E748-E756

[5] Libby G(2010)Metformin against TGFβ-induced epithelial-to-mesenchymal transition (EMT): from cancer stem cells to aging-associated fibrosis Cell Cycle 9 4461-4468

[6] Donnelly LA(2006)Mechanisms of drug inhibition of signalling molecules Nature 441 457-462

[7] Donnan PT(2004)Targeting the mitogen activated protein kinase cascade to treat cancer Nat Rev Cancer 4 937-947

[8] Dowling RJ(2007)Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer Oncogene 26 3291-3310

[9] Zakikhani M(2010)Snail family regulation and epithelial mesenchymal transitions in breast cancer progression J Mammary Gland Biol Neoplasia 15 135-147

[10] Fantus IG(2003)Tumor suppressor gene E-cadherin and its role in normal and malignant cells Cancer Cell Int 3 17-6929

[1] Hawley S(2002)The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism Diabetes 51 2420-2425

[2] Gadalla AE(2009)New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes Diabetes Care 32 1620-1625

[3] Olsen GS(2007)Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells Cancer Res 67 10804-10812

[4] Grahame Hardie D(2015)A novel dual AMPK activator/mTOR inhibitor inhibits thyroid cancer cell growth J Clin Endocrinol Metab 100 E748-E756

[5] Libby G(2010)Metformin against TGFβ-induced epithelial-to-mesenchymal transition (EMT): from cancer stem cells to aging-associated fibrosis Cell Cycle 9 4461-4468

[6] Donnelly LA(2006)Mechanisms of drug inhibition of signalling molecules Nature 441 457-462

[7] Donnan PT(2004)Targeting the mitogen activated protein kinase cascade to treat cancer Nat Rev Cancer 4 937-947

[8] Dowling RJ(2007)Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer Oncogene 26 3291-3310

[9] Zakikhani M(2010)Snail family regulation and epithelial mesenchymal transitions in breast cancer progression J Mammary Gland Biol Neoplasia 15 135-147

[10] Fantus IG(2003)Tumor suppressor gene E-cadherin and its role in normal and malignant cells Cancer Cell Int 3 17-6929