Sequential combination therapy with interferon, interleukin-2 and therapeutic vaccine in entecavir-suppressed chronic hepatitis B patients: the Endeavor study

被引：0
作者：
Di Wu
Peng Wang
Meifang Han
Yongping Chen
Xinyue Chen
Qi Xia
Weiming Yan
Xiaoyang Wan
Chuanlong Zhu
Qing Xie
Jiaji Jiang
Lai Wei
Deming Tan
Xiaoguang Dou
Yanyan Yu
Jinlin Hou
Xiaoping Luo
Qin Ning
机构：
[1] Huazhong University of Science and Technology,Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College
[2] The First Affiliated Hospital of Wenzhou Medical University,Department of Infectious Disease
[3] Capital Medical University,International Medical Department, Beijing You’an Hospital
[4] Zhejiang University,State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine
[5] Anhui Medical University,Department of Infectious Disease, Anhui Provincial Hospital
[6] Jiaotong University School of Medicine,Department of Infectious Diseases, Shanghai Ruijin Hospital
[7] First Affiliated Hospital of Fujian Medical University,Liver Research Center
[8] Peking University People’s Hospital,Department of Hepatology
[9] Central South University,Department of Infectious Diseases, Xiangya Hospital
[10] Shengjing Hospital of China Medical University,Department of Infectious Disease
[11] Peking University First Hospital,Department of Infectious Diseases
[12] Southern Medical University,Department of Infectious Diseases, Nanfang Hospital
[13] Huazhong University of Science and Technology,Department of Pediatrics, Tongji Hospital, Tongji Medical College
来源：
Hepatology International | 2019年 / 13卷
关键词：
Hepatitis B surface antigen loss; Interferon; Entecavir; Combination therapy;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：573 / 586
页数：13
相关论文
共 266 条
[41]  
Hadziyannis S(2011)Sequential therapy with adefovir dipivoxil and pegylated interferon alfa-2a for HBeAg-negative patients J Viral Hepat 18 580-172
[42]  
Jin R(1987)Effects of human recombinant interleukin 2 in patients with chronic hepatitis B: a preliminary report Am J Gastroenterol 82 438-S55
[43]  
Chang TT(1988)Effects of recombinant interleukin 2 on immunological effector cells of the peripheral blood in patients with HBe antigen-positive chronic hepatitis Gastroenterol Jpn 23 147-358
[44]  
Lai CL(1998)Double-blind, randomized controlled trial of interleukin-2 treatment of chronic hepatitis B J Med Virol 54 167-1362
[45]  
Kew Yoon S(1993)Treatment of chronic hepatitis B with interferon alpha-2b and interleukin-2 J Hepatol 17 S52-83
[46]  
Lee SS(2009)Regulatory NK-cell functions in inflammation and autoimmunity Mol Med 15 352-267
[47]  
Coelho HS(2018)CD56(bright) natural killer cells induce HBsAg reduction via cytolysis and cccDNA decay in long-term entecavir-treated patients switching to peginterferon alfa-2a J Viral Hepat 25 1352-undefined
[48]  
Carrilho FJ(2016)Interferon alpha induces sustained changes in NK cell responsiveness to hepatitis B viral load suppression in vivo PLoS Pathog 12 e1005788-undefined
[49]  
Marcellin P(2017)Low hepatitis B virus-specific T-cell response in males correlates with high regulatory T-cell numbers in murine models Hepatology 66 69-undefined
[50]  
Heathcote EJ(1993)Pilot study of natural human interleukin-2 in patients with chronic hepatitis B immunomodulatory and antiviral effects J Hepatol 19 259-undefined
12345678910