Cartap and carbofuran induced alterations in serum lipid profile of Wistar rats

被引：18

作者：

Rai D.K. ^{[1
]}

Rai P.K. ^{[2
]}

Gupta A. ^{[1
]}

Watal G. ^{[2
]}

Sharma B. ^{[1
]}

机构：

[1] Department of Biochemistry, University of Allahabad

[2] Medicinal Research Lab, Department of Chemistry, University of Allahabad

来源：

Indian Journal of Clinical Biochemistry | 2009年 / 24卷 / 2期

关键词：

Carbofuran; Cartap; Lipid; Triglyceride; Wistar rats;

D O I：

10.1007/s12291-009-0036-8

中图分类号：

学科分类号：

摘要：

Wistar rats of 6-8 weeks in age weighing between 120-150 g were exposed to the fixed doses of each of the carbamate pesticides such as cartap (50% LD50) and carbofuran (50% LD50) as well as a combination of these two with 25% LD50 of each for one week. The effect of treatments was studied in terms of serum lipid parameters such as high-density lipoprotein, total cholesterol, triglyceride, low-density lipoprotein and very low-density lipoprotein. Treatment with individual doses of carbofuran (50% LD50) and cartap (50 % LD50) caused significant alterations in the levels of serum lipid parameters. The pesticides treatment resulted in marked decrease in the level of serum high-density lipoprotein where as that of other lipids got significantly elevated. Further, the rats exhibited relatively higher impact of pesticides when treated with the compounds in combination (25 % LD50 of each). The results indicated that these compounds when used together may exert enhanced effect on the levels of serum lipids in rat. © 2009 Association of Clinical Biochemists of India.

引用

页码：198 / 201

页数：3

共 16 条

[1]

Whyatt R.M., Barr D.B., Camann D.E., Kinney P.L., Barr J.R., Andrews H.F., Et al., Contemporary use pesticides in personal air samples during pregnancy and blood samples at delivery among urban minority mothers and newborns, Environ Health Perspect, 111, pp. 749-756, (2003)

[2]

Gupta R.C., Carbofuran toxicity, J Toxicol Environ Health, 43, pp. 383-418, (1994)

[3]

Risher J.F., Mink F.L., Stara J.F., The toxicologic effects of the carbamate insecticide aldicarb in mammals: A review, Environ Health Perspect, 72, pp. 267-281, (1987)

[4]

Fukuto T.R., Mechanism of action of organophosphorus and carbamate pesticides, Environ Health Perspect, 87, pp. 245-254, (1990)

[5]

Pineiro-Carrero V.M., Pineiro E.O., Liver, Pediatrics, 113, pp. 1097-1106, (2004)

[6]

Kareem M., Bedirli N., Neslihan Gurbuz N., Ekinci O., Bedirli A., Akkaya T., Sakrak O., Pasaoglu H., Effects of acute fenthion toxicity on liver and kidney function and histology in rats, Turk J Med Sci, 37, 5, pp. 281-288, (2007)

[7]

Bindali B.B., Kaliwal B.B., Anti-implantation Effect of a Carbamate Fungicide Mancozeb in Albino Mice, Industrial Health, 40, pp. 191-197, (2002)

[8]

Gupta R.C., Goad J.T., Kadel W.L., In vivo acute effects of carbofuran on protein lipid and lipoproteins in rat liver and serum, J Toxicol Environ Health, 42, pp. 451-462, (1994)

[9]

Slotkin T.A., Brown K.K., Seidler F.J., Developmental exposure of rats to chlorpyrifos elicits sex-selective hyperlipidemia and hyperinsulinemia in adulthood, Environ Health Perspect, 113, 10, pp. 1291-1294, (2005)

[10]

Sadek M., Samaan H., Garawany E.-A., Garawany A.E., The in vivo and in vitro inhibition of serum aminotransferases by acetylcholinesterases by anticholinesterase insecticides in rats, Egypt Pharmaceut Sci, 30, pp. 437-444, (1989)

← 1 2 →