Mannan-Binding lectin in asthma and allergy

被引：0
|
作者：
Savneet Kaur
Steffen Thiel
P. Usha Sarma
Taruna Madan
机构：
[1] Institute of Genomics and Integrative Biology,Department of Molecular Biochemistry and Diagnostics
来源：
Current Allergy and Asthma Reports | 2006年 / 6卷
关键词：
Asthma; Allergic Rhinitis; Allergic Disease; Visceral Leishmaniasis; Allergy Clin Immunol;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Mannan-binding lectin (MBL) is a vital and versatile component of innate immunity. It is present in serum and may bind to a plethora of microbial pathogens and mediate opsonization of these by complement-dependent and/or independent mechanisms. Low-MBL levels in serum, attributed to certain genetic polymorphisms, constitute a major factor predisposing to several infectious diseases. However, recent studies propose that MBL extends beyond its classic role as a first-line hostdefense molecule to a modulator of inflammation. In this review, we summarize and explore this potential and a possible novel role of MBL in asthma and allergy.
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页码：377 / 383
页数：6
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