Modeling drug release from functionalized magnetic nanoparticles actuated by non-heating low frequency magnetic field

被引：0
作者：
Y. Golovin
D. Golovin
N. Klyachko
A. Majouga
A. Kabanov
机构：
[1] M.V. Lomonosov Moscow State University,School of Chemistry
[2] G.R. Derzhavin Tambov State University,Center for Nanotechnology in Drug Delivery, UNC Eshelman School of Pharmacy
[3] National Research Technological University “MISIS”,undefined
[4] University of North Carolina at Chapel Hill,undefined
来源：
Journal of Nanoparticle Research | 2017年 / 19卷
关键词：
Magnetic nanoparticles; Controlled release; Modeling; Drug delivery; Drug release acceleration;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Various plausible acceleration mechanisms of drug release from nanocarriers composed of a single-domain magnetic nanoparticle core with attached long macromolecule chains activated by low frequency non-heating alternating magnetic field (AMF) are discussed. The most important system characteristics affecting the AMF exposure impact are determined. Impact of several reasonable mechanisms is estimated analytically or obtained using numerical modeling. Some conditions providing manifold release acceleration as a result from exposure in AMF are found.
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[1]  
Abakumov MA(2015)VEGF-targeted magnetic nanoparticles for MRI visualization of brain tumor Nanomedicine: Nanotechnology, Biology, and Medicine 11 825-833
[2]  
Nukolova NV(2014)Magnetic nanoparticle clusters as actuators of ssDNA release Phys Chem Chem Phys 16 10023-10031
[3]  
Sokolsky-Papkov M(2006)Interaction of functionalized superparamagnetic iron oxide nanoparticles with brain structures J Pharmacol Exp Ther 318 108-116
[4]  
Shein SA(2015)Non-chemotoxic induction of cancer cell death using magnetic nanowires Int J Nanomedicine 10 2141-143
[5]  
Sandalova TO(2008)Remote control of cellular behaviour with magnetic nanoparticles Nat Nanotechnol 3 139-96
[6]  
Vishwasrao HM(2010)Cancer therapy: a twist on tumour targeting Nat Mater 9 95-177
[7]  
Grinenko NF(2006)Principles and design of a novel magnetic force mechanical conditioning bioreactor for tissue engineering, stem cell conditioning, and dynamic in vitro screening IEEE Trans Nanobioscience 5 173-452029
[8]  
Gubsky IL(2014)Magnetic particle hyperthermia—a promising tumour therapy? Nanotechnology 25 452001-1351
[9]  
Abakumov AM(2014)Single-domain magnetic nanoparticles in an alternating magnetic field as mediators of local deformation of the surrounding macromolecules Phys Solid State 56 1342-60
[10]  
Kabanov AV(2015)Towards nanomedicines of the future: remote magneto-mechanical actuation of nanomedicines by alternating magnetic fields J Control Release 219 43-243
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