PPARβ/δ governs Wnt signaling and bone turnover

被引：0

作者：

Carina Scholtysek

Julia Katzenbeisser

He Fu

Stefan Uderhardt

Natacha Ipseiz

Cornelia Stoll

Mario M Zaiss

Michael Stock

Laura Donhauser

Christina Böhm

Arnd Kleyer

Andreas Hess

Klaus Engelke

Jean-Pierre David

Farida Djouad

Jan Peter Tuckermann

Béatrice Desvergne

Georg Schett

Gerhard Krönke

机构：

[1] University of Erlangen-Nürnberg,Department of Internal Medicine 3 and Institute for Clinical Immunology

[2] Nikolaus Fiebiger Center of Molecular Medicine,undefined

[3] University of Erlangen-Nürnberg,undefined

[4] Center of Integrative Genomics,undefined

[5] Faculty of Biology and Medicine,undefined

[6] University of Lausanne,undefined

[7] Institute of Experimental and Clinical Pharmacology and Toxicology,undefined

[8] University of Erlangen-Nürnberg,undefined

[9] Institute of Medical Physics,undefined

[10] University of Erlangen-Nürnberg,undefined

[11] Institut National de la Santé et de la Recherche Médicale,undefined

[12] U844,undefined

[13] University of Montpellier 1,undefined

[14] Unité de Formation et de Recherche (UFR) de Médecine,undefined

[15] Leibniz Institute for Age Research,undefined

[16] Fritz Lipmann Institute,undefined

[17] Institute of General Zoology and Endocrinology,undefined

[18] University of Ulm,undefined

来源：

Nature Medicine | 2013年 / 19卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Gerhard Krönke and his colleagues show that PPARβ/δ regulates Wnt signaling in osteoblasts, which in turn determines the proper ratio of OPG to RANKL and thus bone homeostasis. They go on to show that pharmacological activation of this receptor normalizes bone density in a mouse model of osteoporosis.

引用

页码：608 / 613

页数：5

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