Vitamin C and E in Fluoride Induced Uterine Oxidative Stress and Apoptotic Gene Expression in Wistar Rats

被引：0

作者：

Maity P.P. ^{[1
,2
]}

Dash M. ^{[1
,2
]}

Dey A. ^{[1
,2
]}

Maity M. ^{[1
,2
]}

Chattopadhyay S. ^{[1
,2
]}

机构：

[1] Department of Biomedical Laboratory Science and Management, Vidyasagar University, Midnapore, 721102, West Bengal

[2] Clinical Nutrition and Dietetics Division, Vidyasagar University, Midnapore, 721102, West Bengal

来源：

Proceedings of the Zoological Society | 2021年 / 74卷 / 2期

关键词：

Apoptosis; Inflammation; NaF; Oxidative stress; Uterus; Vitamin C and E;

D O I：

10.1007/s12595-021-00362-w

中图分类号：

学科分类号：

摘要：

Management of fluoride (F) driven abnormalities is a great challenge. The present study emphasized on the abrogation of F facilitated uterine dysfunction by vitamin C and E. In the present investigation Wistar rats were fed with 200 ppm NaF at the dose of 10 mg/kg body weight orally for 28 days along with co-treatment with vitamin C and E at the doses of 50 mg/kg body weight and 15 mg/kg body weight, respectively. F treated group presented a concomitant decrease in the activity of uterine superoxide dismutase (SOD) and catalase (CAT). F ingestion developed up-regulation of tumor necrosis factor (TNF-α) and nuclear factor κB (NF-κB). The pro-apoptotic genes Bax and p53 expressions in uterine tissue were raised in response to fluoridation followed by suppression of anti-apoptotic gene Bcl-2. Vitamin C and E employed its constructive action against F intoxication by weakening TNF-α and NF-κB followed by a promotion of Bcl-2 expression along with Bax and p53 suppression. However, present investigation established the anti-oxidative, anti-inflammatory and anti-apoptotic events of Vitamin C and E. © 2021, Zoological Society, Kolkata, India.

引用

页码：189 / 197

页数：8

共 45 条

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