Increased serum complement C3 and C4 concentrations and their relation to severity of chronic spontaneous urticaria and CRP concentration

被引：0

作者：

Alicja Kasperska-Zajac

Alicja Grzanka

Edyta Machura

Maciej Misiolek

Bogdan Mazur

Jerzy Jochem

机构：

[1] Allergology and Clinical Immunology,Clinical Department of Internal Diseases

[2] Medical University of Silesia in Katowice,Department of Internal Diseases, Dermatology and Allergology

[3] Medical University of Silesia,Department of Pediatric in Zabrze

[4] Medical University of Silesia,Clinical Department of Otolaryngology in Zabrze

[5] Medical University of Silesia,Department of Microbiology and Immunology

[6] Medical University of Silesia,Department of Basic Medical Sciences

来源：

Journal of Inflammation | / 10卷

关键词：

Complement; C3; C4; Acute phase response; Chronic urticaria;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Chronic spontaneous urticaria (CU) is associated with activation of the acute phase response (APR). Nevertheless, APR-associated proteins have not been well characterized as potential biomarkers of the disease severity. To assess the pattern of complement proteins C3 and C4 – the acute phase reactants in patients with CU. C3, C4 and CRP concentrations were measured in serum of 70 patients showing different degrees of urticarial severity as well as in 33 healthy subjects. Serum C3 and C4 concentrations were significantly increased in CU patients as compared with the healthy subjects and exceed the normal lab range by about 5% and 10%, respectively. Significant differences were found between patients with mild and increased CU severity. In addition, significant correlations were observed between C3, C4 and CRP concentrations. More severe CU is characterized by higher production of C3 and C4 complements accompanied by parallel changes in CRP concentration.

引用

共 80 条

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