Low prevalence of human papillomavirus infection in sinonasal inverted papilloma and oncocytic papilloma

被引：0
作者：
Huan Wang
Changwen Zhai
Juan Liu
Jingjing Wang
Xicai Sun
Li Hu
Dehui Wang
机构：
[1] Fudan University,Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital
[2] Fudan University,Department of Clinical Pathology, Eye, Ear, Nose and Throat Hospital
[3] Fudan University,Department of Clinical Laboratory, Eye, Ear, Nose and Throat Hospital
[4] Fudan University,Department of Experimental Center, Eye, Ear, Nose and Throat Hospital
来源：
Virchows Archiv | 2020年 / 476卷
关键词：
Inverted papilloma; Oncocytic papilloma; Human papillomavirus; p16;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The aim of this study was to investigate the role of human papillomavirus (HPV) in sinonasal inverted papilloma (SIP) and sinonasal oncocytic papilloma (SOP) from a single institution and whether p16 can serve as a surrogate marker for HPV infection. This study included 49 subjects with SIP and 36 subjects with SOP. Formalin-fixed paraffin-embedded tissues were used to extract genomic DNA, and HPV detection was performed by utilizing a valid nested polymerase chain reaction approach that can detect all known HPV subtypes. Immunohistochemistry was used to evaluate the expression of p16 in all tumor sections. The presence of HPV DNA was found in 6.1% (3/49) of the SIP patients and 11.1% (4/36) of the SOP patients. All identified HPV subtypes in SIP were high-risk HPV, including HPV-16 (two patients) and HPV-58 (one patient). Regarding SOP, there were three patients positive for HPV-16 and one with low-risk HPV (type 6). In total, 11/49 (22.4%) SIP lesions and 10/36 (27.8%) SOP lesions were considered p16 positive, with p16 staining in more than 70% of tumor cells. There was only one SIP and one SOP that were positive for both HPV (high-risk HPV type 16) and p16 staining. HPV does not play an etiologic role in inverted papilloma or oncocytic papilloma of the sinonasal region. p16 immunostaining should not be used as a surrogate marker to evaluate the HPV infection status in these lesions.
引用
收藏
页码：577 / 583
页数：6
相关论文
共 35 条
[11]  
Syrjanen KJ(2016)Roles of human papillomavirus infection and stathmin in the pathogenesis of sinonasal inverted papilloma Head Neck 38 220-1074
[12]  
Mohajeri S(2017)Role of the Akt/mTOR signaling pathway in human papillomavirus-associated nasal and sinonasal inverted papilloma Acta Biochim Biophys Sin Shanghai 49 1067-533
[13]  
Rooper LM(2012)Prevalence of human papillomavirus, Epstein-Barr virus, p21, and p53 expression in sinonasal inverted papilloma, nasal polyp, and hypertrophied turbinate in Hong Kong patients Head Neck 34 520-968
[14]  
Bishop JA(2000)Development of a staging system for inverted papilloma Laryngoscope 110 965-93
[15]  
Westra WH(2004)Nested PCR with the PGMY09/11 and GP5(+)/6(+) primer sets improves detection of HPV DNA in cervical samples J Virol Methods 122 87-597
[16]  
Vorasubin N(2018)Human papillomavirus testing in head and neck carcinomas: guideline from the College of American Pathologists Arch Pathol Lab Med 142 559-1000
[17]  
Syrjanen K(2013)COX-(2) overexpression in sinonasal inverted papilloma Int Forum Allergy Rhinol 3 997-516
[18]  
Syrjanen S(2014)Overexpression of angiomotin in sinonasal inverted papilloma Int Forum Allergy Rhinol 4 512-94
[19]  
Lin H(2012)Human papillomavirus load and physical status in sinonasal inverted papilloma and squamous cell carcinoma Rhinology 50 87-538
[20]  
Lin D(2011)In inverted papillomas HPV more likely represents incidental colonization than an etiological factor Virchows Arch 459 529-471
1234