PIK3R1 underexpression is an independent prognostic marker in breast cancer

[1] Katayama K(2005)Akt/protein kinase B-dependent phosphorylation and inactivation of WEE1Hu promote cell cycle progression at G2/M transition Mol Cell Biol 25 5725-5737

[2] Fujita N(2009)GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer Nature 459 1085-1090

[3] Tsuruo T(2011)Targeting the phosphoinositide-3 (PI3) kinase pathway in breast cancer Oncologist 16 12-19

[4] Scott KL(2008)An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer Cancer Res 68 6084-6091

[5] Kabbarah O(2010)Phosphatidylinositol-3-kinase and AKT1 mutations occur early in breast carcinoma Breast Cancer Res Treat 120 409-418

[6] Liang MC(2010)The phosphatidyl inositol 3-kinase/AKT signaling pathway in breast cancer Cancer Metastasis Rev 29 751-759

[7] Ivanova E(2005)Mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit J Biol Chem 280 27850-27855

[8] Anagnostou V(2007)Different prognostic roles of mutations in the helical and kinase domains of the PIK3CA gene in breast carcinomas Clin Cancer Res 13 6064-6069

[9] Wu J(2007)Clinicopathologic analysis of breast cancers with PIK3CA mutations in Japanese women Clin Cancer Res 13 408-414

[10] Dhakal S(2007)PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer Clin Cancer Res 13 3577-3584

[1] Katayama K(2005)Akt/protein kinase B-dependent phosphorylation and inactivation of WEE1Hu promote cell cycle progression at G2/M transition Mol Cell Biol 25 5725-5737

[2] Fujita N(2009)GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer Nature 459 1085-1090

[3] Tsuruo T(2011)Targeting the phosphoinositide-3 (PI3) kinase pathway in breast cancer Oncologist 16 12-19

[4] Scott KL(2008)An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer Cancer Res 68 6084-6091

[5] Kabbarah O(2010)Phosphatidylinositol-3-kinase and AKT1 mutations occur early in breast carcinoma Breast Cancer Res Treat 120 409-418

[6] Liang MC(2010)The phosphatidyl inositol 3-kinase/AKT signaling pathway in breast cancer Cancer Metastasis Rev 29 751-759

[7] Ivanova E(2005)Mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit J Biol Chem 280 27850-27855

[8] Anagnostou V(2007)Different prognostic roles of mutations in the helical and kinase domains of the PIK3CA gene in breast carcinomas Clin Cancer Res 13 6064-6069

[9] Wu J(2007)Clinicopathologic analysis of breast cancers with PIK3CA mutations in Japanese women Clin Cancer Res 13 408-414

[10] Dhakal S(2007)PIK3CA mutations and PTEN loss correlate with similar prognostic factors and are not mutually exclusive in breast cancer Clin Cancer Res 13 3577-3584