Structure of the insulin receptor–insulin complex by single-particle cryo-EM analysis

被引：0
作者：
Giovanna Scapin
Venkata P. Dandey
Zhening Zhang
Winifred Prosise
Alan Hruza
Theresa Kelly
Todd Mayhood
Corey Strickland
Clinton S. Potter
Bridget Carragher
机构：
[1] Merck & Co.,Department of Biochemical Engineering & Structure
[2] Simons Electron Microscopy Center,Department of Biophysics
[3] National Resource for Automated Molecular Microscopy,undefined
[4] New York Structural Biology Center,undefined
[5] Merck & Co.,undefined
[6] NMR & Protein Products Characterization,undefined
来源：
Nature | 2018年 / 556卷
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学科分类号：
摘要：
Cryo-electron microscopy structures of insulin in a complex with the insulin receptor define the S2 binding site on the receptor and suggest a mechanism for downstream propagation of insulin signalling.
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页码：122 / 125
页数：3
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