Structure of the insulin receptor–insulin complex by single-particle cryo-EM analysis

被引:0
作者
Giovanna Scapin
Venkata P. Dandey
Zhening Zhang
Winifred Prosise
Alan Hruza
Theresa Kelly
Todd Mayhood
Corey Strickland
Clinton S. Potter
Bridget Carragher
机构
[1] Merck & Co.,Department of Biochemical Engineering & Structure
[2] Simons Electron Microscopy Center,Department of Biophysics
[3] National Resource for Automated Molecular Microscopy,undefined
[4] New York Structural Biology Center,undefined
[5] Merck & Co.,undefined
[6] NMR & Protein Products Characterization,undefined
来源
Nature | 2018年 / 556卷
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摘要
Cryo-electron microscopy structures of insulin in a complex with the insulin receptor define the S2 binding site on the receptor and suggest a mechanism for downstream propagation of insulin signalling.
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页码:122 / 125
页数:3
相关论文
共 89 条
[1]  
Saltiel AR(2001)Insulin signalling and the regulation of glucose and lipid metabolism Nature 414 799-806
[2]  
Kahn CR(1989)Insulin and insulin-like growth factor receptors in the nervous system Mol. Neurobiol. 3 71-100
[3]  
Adamo M(2008)The role of insulin receptors and IGF-I receptors in cancer and other diseases Arch. Physiol. Biochem. 114 23-37
[4]  
Raizada MK(2012)Alzheimer disease: insulin resistance and AD—extending the translational path Nat. Rev. Neurol. 8 360-362
[5]  
LeRoith D(1989)Structure of the human insulin receptor gene and characterization of its promoter Proc. Natl Acad. Sci. USA 86 114-118
[6]  
Frasca F(2015)Insulin/receptor binding: the last piece of the puzzle? What recent progress on the structure of the insulin/receptor complex tells us (or not) about negative cooperativity and activation BioEssays 37 389-397
[7]  
Craft S(2013)How insulin engages its primary binding site on the insulin receptor Nature 493 241-245
[8]  
Seino S(2006)Structure of the insulin receptor ectodomain reveals a folded-over conformation Nature 443 218-221
[9]  
Seino M(2010)Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists Proc. Natl Acad. Sci. USA 107 6771-6776
[10]  
Nishi S(2016)Higher-resolution structure of the human insulin receptor ectodomain: multi-modal inclusion of the insert domain Structure 24 469-476