Mechanisms of Granulocytopoiesis Recovery Stimulation with Filgrastim in Breast Cancer Patients Receiving Chemotherapy

被引：0
作者：
V. E. Goldberg
T. Yu. Polyakova
N. O. Popova
V. V. Vysotskaya
E. I. Simolina
E. A. Dudnikova
N. M. Goncharova
Yu. V. Belevich
T. P. Tuzikova
A. V. Goldberg
L. A. Miroshnichenko
E. V. Udut
E. V. Simanina
G. N. Zyuz’kov
V. V. Zhdanov
A. M. Dygai
机构：
[1] Tomsk Research Medical Center of the Russian Academy of Sciences,Research Institute of Oncology
[2] Tomsk Research Medical Center of the Russian Academy of Sciences,E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine
[3] National Research Tomsk State University,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2018年 / 166卷
关键词：
granulocyte colony-stimulating factor; breast cancer; chemotherapy; granulocytopoiesis; myelosuppression;
D O I：
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中图分类号：
学科分类号：
摘要：
We studied myelotoxicity of modern schemes of chemotherapy for breast cancer (docetaxel/doxorubicin and cyclophosphamide/doxorubicin/5-fluorouracil) towards granulocytopoiesis, the mechanisms determining the differences of hematological effects of these schemes, and the efficiency of correction of the observed changes with granulocyte CSF (filgrastim). Granulocytopoiesis stimulation with filgrastim during the treatment with docetaxel/doxorubicin combination was more pronounced than during cyclophosphamide/doxorubicin/5-fluorouracil therapy. The observed differences were found at all levels of granulocyte lineage organization (central and peripheral), which is related to different effects of the cytostatic substances used in the proposed protocols on the structures controlling hemopoiesis.
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页码：63 / 68
页数：5
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