Primary gastric small cell carcinoma: Report of a case and review of the literature

被引：33

作者：

Namikawa T. ^{[1
]}

Kobayashi M. ^{[1
]}

Okabayashi T. ^{[1
]}

Ozaki S. ^{[2
]}

Nakamura S. ^{[2
]}

Yamashita K. ^{[2
]}

Ueta H. ^{[3
]}

Miyazaki J. ^{[4
]}

Tamura S. ^{[5
]}

Ohtsuki Y. ^{[6
]}

Araki K. ^{[1
]}

机构：

[1] Department of Tumor Surgery, Kochi Medical School, Nankoku, Kochi 783-8505, Kohasu-Okocho

[2] Department of Surgery, Kochi Prefectural Hata Kenmin Hospital, Kochi

[3] Department of Gastroenterology and Hepatology, Kochi Prefectural Hata Kenmin Hospital, Kochi

[4] Department of Clinical Pathology, Kochi Prefectural Hata Kenmin Hospital, Kochi

[5] Department of Endoscopy, Kochi Medical School, Kochi

[6] Department of Tumor Pathology, Kochi Medical School, Kochi

来源：

Medical Molecular Morphology | 2005年 / 38卷 / 4期

关键词：

Chemotherapy; Electron-dense core granule; Gastric carcinoma; Small cell carcinoma; Surgical resection;

D O I：

10.1007/s00795-005-0293-4

中图分类号：

学科分类号：

摘要：

A 52-year-old man suffering from a pure-type primary gastric small cell carcinoma was treated with surgery and combination chemotherapy. The small cell carcinoma, approximately 6.5cm in diameter, was situated in the posterior wall of the antrum and there were no distant metasatses. Total gastrectomy and regional lymph node dissection was carried out. Histological examination revealed a solid pattern of proliferation of small cells with hyperchromatic, round nuclei and scant cytoplasm. Neoplastic cells infiltrated into the subserosal layer with severe lymphatic and vascular invasion. Regional lymph node cells were mostly replaced by tumor cells that stained positive for Grimelius, neuron-specific enolase (NSE), and synaptophysin. Accumulations of electron-dense core granules in the small neoplastic cells were seen by electron microscopy. Following surgery, the patient was treated with adjuvant chemotherapy consisting of cisplatin and etoposide. The patient is alive and recurrence free 3 years after surgical operation. We review 107 published cases of primary gastric small cell carcinoma, an extremely rare disease first reported in 1976. Small cell carcinoma is an aggressive, malignant tumor. Intensive chemotherapy is essential for patient survival even when curative surgical resection is carried out. © The Japanese Society for Clinical Molecular Morphology 2005.

引用

页码：256 / 261

页数：5

共 17 条

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