The role of the HERG channel in the secretion of glucagon-like peptide-1 (GLP-1) from murine intestinal L-cells

被引：0

作者：

Ying-Chao Yuan

Chang Liu

Rong-Rong Xie

Lin Zhang

Hao Wang

Jin-Kui Yang

机构：

[1] Beijing Diabetes Institute,Beijing Key Laboratory of Diabetes Research and Care

[2] Beijing Tongren Hospital,Department of Endocrinology and Metabolism

[3] Capital Medical University,Laboratory for Clinical Medicine

[4] Beijing Tongren Hospital,Department of Medical Record

[5] Capital Medical University,undefined

[6] Capital Medical University,undefined

[7] Beijing Tongren Hospital,undefined

[8] Capital Medical University,undefined

来源：

Current Medicine | / 2卷 / 1期

关键词：

Glucagon-like peptide-1; GLP-1; Kv channel; GLUTag; L-cell;

D O I：

10.1007/s44194-023-00022-5

中图分类号：

学科分类号：

摘要：

The HERG ion channel belongs to the voltage-gated potassium (Kv) channel family and is involved in potassium efflux during cellular repolarization. Mutations in HERG have been linked to long QT syndrome, which is associated with elevated secretion of glucagon-like peptide-1 (GLP-1). However, the precise contribution of HERG to GLP-1 secretion remains unclear. In this study, we demonstrate the expression of HERG in GLP-1-producing L-cells within the intestinal epithelium of rodents. Using a mouse L-cell model (GLUTag cell line), we observed that downregulation of HERG led to a significant prolongation of action potential duration, an increase in intracellular calcium concentration, and a stimulation of GLP-1 secretion following exposure to nutrients. These findings provide evidence that HERG plays a direct role in regulating GLP-1 secretion in the intestine and may hold promise as a potential target for the treatment of diabetes.

引用

共 36 条

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