The role of long non-coding RNA BCAR4 in human cancers

被引：0
作者：
Qiong Yi
Zhongcheng Liu
Kun Zhang
Xuening Liu
Lifu Wang
Bin Geng
Yayi Xia
机构：
[1] Lanzhou University Second Hospital,Department of Orthopaedics
[2] Orthopaedics Key Laboratory of Gansu Province,undefined
[3] Orthopaedic Clinical Medical Research Center of Gansu Province,undefined
来源：
Human Cell | 2021年 / 34卷
关键词：
lncRNA; BCAR4; Cancer; Biomarker; Mechanism;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Long non-coding RNA (lncRNA) is a type of non-coding RNA with length of nucleotides > 200 bp. Increasing evidences show that lncRNA breast cancer antiestrogen resistance 4 (BCAR4) plays an important role in the occurrence and development of various human cancers. It is found that BCAR4 is highly expressed in diverse tumor tissues and cells, and the high expression of BCAR4 is usually associated with poor prognosis. BCAR4 is considered as an oncogene in human cancers. By competing endogenous RNA (ceRNA) mechanism and regulating different signaling pathways, BCAR4 participates in the proliferation, apoptosis, migration, invasion, epithelial-mesenchymal transition (EMT), metastasis and tumorigenesis of different cancers. In addition, overexpression of BCAR4 promotes drug resistance of tumor cells. Therefore, BCAR4 is a promising biomarker for cancer diagnosis and prognosis, and it is a potential target for cancer therapy. This paper reviews studies focusing on the relationship between BCAR4 and cancers in recent years and aims to summarize the effect and mechanism of BCAR4 in human cancers.
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页码：1301 / 1309
页数：8
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[1]  
Li Z(2016)TUG1: a pivotal oncogenic long non-coding RNA of human cancers Cell Prolif 49 471-475
[2]  
Shen J(2018)MIR100 host gene-encoded lncRNAs regulate cell cycle by modulating the interaction between HuR and its target mRNAs Nucleic Acids Res 46 10405-10416
[3]  
Chan MT(2017)The emergence of noncoding RNAs as heracles in autophagy Autophagy 13 1004-1024
[4]  
Wu WK(2016)Mechanisms of long noncoding RNA function in development and disease Cell Mol Life Sci 73 2491-2509
[5]  
Sun Q(2016)Long non-coding RNA MALAT1 is up-regulated in ovarian cancer tissue and promotes SK-OV-3 cell proliferation and invasion Neoplasma 63 865-872
[6]  
Tripathi V(2016)The lncRNA MALAT1 is a novel biomarker for gastric cancer metastasis Oncotarget 7 56209-56218
[7]  
Yoon JH(2015)MALAT1 promotes the proliferation and metastasis of osteosarcoma cells by activating the PI3K/Akt pathway Tumour Biol J Int Soc Oncodev Biol Med 36 1477-1486
[8]  
Singh DK(2015)LINC00152 promotes proliferation in hepatocellular carcinoma by targeting EpCAM via the mTOR signaling pathway Oncotarget 6 42813-42824
[9]  
Hao Q(2016)A novel long noncoding RNA-LOWEG is low expressed in gastric cancer and acts as a tumor suppressor by inhibiting cell invasion J Cancer Res Clin Oncol 142 601-609
[10]  
Min KW(2014)The decalog of long non-coding RNA involvement in cancer diagnosis and monitoring Crit Rev Clin Lab Sci 51 344-357
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