Proof-of-concept recall-by-genotype study of extremely low and high Alzheimer’s polygenic risk reveals autobiographical deficits and cingulate cortex correlates

被引：0
作者：
Thomas Lancaster
Byron Creese
Valentina Escott-Price
Ian Driver
Georgina Menzies
Zunera Khan
Anne Corbett
Clive Ballard
Julie Williams
Kevin Murphy
Hannah Chandler
机构：
[1] University of Bath,Department of Psychology
[2] Cardiff University Brain Research Imaging Centre,School of Physics and Astronomy
[3] Cardiff University,Dementia Research Institute (UKDRI)
[4] Cardiff University,Department of Clinical and Biomedical Science, Faculty of Health and Life Sciences
[5] University of Exeter,Department of Life Sciences
[6] Brunel University London,Division of Neuroscience and Mental Health, School of Medicine
[7] Cardiff University,School of Biosciences
[8] Cardiff University,Institute of Psychiatry
[9] King’s College London,Deptartment of Health & Community Sciences
[10] University of Exeter,undefined
来源：
Alzheimer's Research & Therapy | / 15卷
关键词：
Polygenic risk score; Alzheimer’s disease; Recall-by-genotype; Neuroimaging;
D O I：
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[1]  
Lambert JC(2013)Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease Nat Genet 45 1452-1458
[2]  
Ibrahim-Verbaas CA(2021)Common variants in Alzheimer's disease and risk stratification by polygenic risk scores Nat Commun 12 3417-322
[3]  
Harold D(2020)The multiplex model of the genetics of Alzheimer's disease Nat Neurosci 23 311-2727
[4]  
Naj AC(2023)Step by step: towards a better understanding of the genetic architecture of Alzheimer's disease Mol Psychiatry. 28 2716-77
[5]  
Sims R(2021)Identifying individuals with high risk of Alzheimer's disease using polygenic risk scores Nat Commun 12 4506-3684
[6]  
Bellenguez C(2020)Polygenic risk scores in Alzheimer's disease: current applications and future directions Front Digit Health 2 14-321
[7]  
de Rojas I(2020)Age-dependent effect of APOE and polygenic component on Alzheimer's disease Neurobiol Aging 93 69-1476
[8]  
Moreno-Grau S(2015)Common polygenic variation enhances risk prediction for Alzheimer's disease Brain : a journal of neurology 138 3673-892
[9]  
Tesi N(2021)Genome-wide association study of brain amyloid deposition as measured by Pittsburgh Compound-B (PiB)-PET imaging Mol Psychiatry 26 309-517
[10]  
Grenier-Boley B(2020)Association between APOE e4 and white matter hyperintensity volume, but not total brain volume or white matter integrity Brain Imaging Behav 14 1468-2760
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