Current Status: Site-Specific Antibody Drug Conjugates

被引：0
|
作者：
Dominik Schumacher
Christian P. R. Hackenberger
Heinrich Leonhardt
Jonas Helma
机构：
[1] Leibniz-Institut für Molekulare Pharmakologie and Humboldt Universität zu Berlin,Chemical Biology and Department of Chemistry
[2] Ludwig-Maximilians-Universität München and Center for Integrated Protein Science Munich,Department of Biology II
来源：
Journal of Clinical Immunology | 2016年 / 36卷
关键词：
Antibody drug conjugates (ADCs); drug-antibody ratio (DAR); site-specific conjugation; therapeutic window; unnatural amino acids (UAA); monomethyl auristatin E/F (MMAE/MMAF); THIOMAB; microbial transglutaminase (MTG); formylglycine generating enzyme (FGE); Sortase A; tubulin tyrosine ligase (TTL); Tub-tag;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Antibody drug conjugates (ADCs), a promising class of cancer biopharmaceuticals, combine the specificity of therapeutic antibodies with the pharmacological potency of chemical, cytotoxic drugs. Ever since the first ADCs on the market, a plethora of novel ADC technologies has emerged, covering as diverse aspects as antibody engineering, chemical linker optimization and novel conjugation strategies, together aiming at constantly widening the therapeutic window for ADCs. This review primarily focuses on novel chemical and biotechnological strategies for the site-directed attachment of drugs that are currently validated for 2nd generation ADCs to promote conjugate homogeneity and overall stability.
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页码：100 / 107
页数：7
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