Comparison of Separation Performances of Cellulose-Based Chiral Stationary Phases in LC Enantioseparation of Aminonaphthol Analogues

The enantiomers of 1-(α-aminoarylmethyl)-2-naphthol, 1-(α-aminoalkyl)-2-naphthol and 2-(α-aminoarylmethyl)-1-naphthol analogues were separated on tris(3,5-dimethylphenyl)carbamoyl cellulose-based CelluCoat and Chiralcel OD-H chiral stationary phases, with n-heptane/alcohol or n-hexane/alcohol as mobile phase. The experimental data are utilised to discuss the effects of the mobile phase composition, the nature of the alcoholic modifier and the specific structural features of the analytes (1- or 2-naphthol analogues with aryl or alkyl substituents) on the retention and separation. The separation performances of CelluCoat and Chiralcel OD-H columns were compared. Due to its high resolution ability and its effectivity, CelluCoat proved to be a good choice for the enantiomeric separation of aminonaphthol analogues.