Emerging Role of Non-coding RNAs in Autism Spectrum Disorder

被引：0

作者：

Soudeh Ghafouri-Fard

Rezvan Noroozi

Serge Brand

Bashdar Mahmud Hussen

Reyhane Eghtedarian

Mohammad Taheri

Kaveh Ebrahimzadeh

机构：

[1] Shahid Beheshti University of Medical Sciences,Department of Medical Genetics, School of Medicine

[2] Jagiellonian University,Malopolska Centre of Biotechnology

[3] University of Basel,Psychiatric Clinics, Center for Affective, Stress and Sleep Disorders

[4] Hawler Medical University,Department of Pharmacognosy, College of Pharmacy

[5] Men’s Health and Reproductive Health Research Center,Urology and Nephrology Research Center

[6] Shahid Beheshti University of Medical Sciences,Institute of Human Genetics

[7] Shahid Beheshti University of Medical Sciences,Skull Base Research Center

[8] Jena University Hospital,undefined

[9] Loghman Hakim Hospital,undefined

[10] Shahid Beheshti University of Medical Sciences,undefined

来源：

Journal of Molecular Neuroscience | 2022年 / 72卷

关键词：

Autism spectrum disorder; lncRNA; miRNA; circRNA;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Autism spectrum disorders (ASD) embrace a diverse set of neurodevelopmental diseases with a multifaceted genetic basis. Non-coding RNAs (ncRNAs) are among putative loci with critical participation in the development of ASD. Expression of some lncRNAs, namely RP11-466P24.2, SYP-AS1, STXBP5-AS1, and IFNG-AS1 has been decreased in ASD, while AK128569, CTD-2516F10.2, MSNP1AS, RPS10P2-AS1, LINC00693, LINC00689, NEAT1, TUG1, and Shank2‐AS lncRNAs have been over-expressed in ASD. Expression of several miRNAs which are implicated in the immunological developmental, immune responses, and protein synthesis as well as those participating in the regulation of PI3K/Akt/mTOR and EGFR signaling pathways is dysregulated in the context of ASD. In the present article, we describe investigations which appraised the role of lncRNAs, miRNAs, and circRNAs in the pathobiology of ASD.

引用

页码：201 / 216

页数：15

共 343 条

[1]

Berkel S(2010)Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation Nat Genet 42 489-357

[2]

Marshall CR(2012)Inherited and de novo SHANK2 variants associated with autism spectrum disorder impair neuronal morphogenesis and physiology Hum Mol Genet 21 344-519

[3]

Weiss B(2019)The long noncoding RNA RPS10P2-AS1 is implicated in autism spectrum disorder risk and modulates gene expression in human neuronal progenitor cells Front Genet 10 970-708

[4]

Howe J(2020)MicroRNAs as regulators of brain function and targets for treatment of epilepsy Nat Rev Neurol 16 506-391

[5]

Roeth R(2015)General hallmarks of microRNAs in brain evolution and development RNA Biol 12 701-91

[6]

Moog U(2020)Genome-wide, integrative analysis of circular RNA dysregulation and the corresponding circular RNA-microRNA-mRNA regulatory axes in autism Genome Res 30 375-1789

[7]

Endris V(2018)Co-expression of long non-coding RNAs and autism risk genes in the developing human brain BMC Syst Biol 12 91-874

[8]

Roberts W(2015)MicroRNAs: not “fine-tuners” but key regulators of neuronal development and function Front Neurol 6 245-333

[9]

Szatmari P(2012)The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression Genome Res 22 1775-54

[10]

Pinto D(2020)Aberrant expression of long non-coding RNAs (lncRNAs) is involved in brain glioma development Arch Med Sci 16 177-1034

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