Arachnoid cysts do not contain cerebrospinal fluid: A comparative chemical analysis of arachnoid cyst fluid and cerebrospinal fluid in adults

被引：27

作者：

Berle M. ^{[1
]}

Wester K.G. ^{[2
,3
]}

Ulvik R.J. ^{[1
,4
]}

Kroksveen A.C. ^{[1
]}

Haaland T.A. ^{[5
]}

Amiry-Moghaddam M. ^{[6
]}

Berven F.S. ^{[7
]}

Helland C.A. ^{[2
,3
]}

机构：

[1] Institute of Medicine, University of Bergen

[2] Institute of Surgical Sciences, Section for Neurosurgery, University of Bergen

[3] Department of Neurosurgery, Haukeland University Hospital

[4] Laboratory of Clinical Biochemistry, Haukeland University Hospital

[5] Department of Mathematics, University of Bergen

[6] Centre for Molecular Biology and Neuroscience, Institute of Basic Medical Sciences, University of Oslo, Oslo

[7] Proteomic Unit (PROBE), Department of Biomedicine, University of Bergen

来源：

Cerebrospinal Fluid Research | / 7卷 / 1期

关键词：

Ferritin; Arachnoid Cyst; Valve Mechanism; Cyst Fluid; Oncotic Pressure;

D O I：

10.1186/1743-8454-7-8

中图分类号：

学科分类号：

摘要：

Background: Arachnoid cyst (AC) fluid has not previously been compared with cerebrospinal fluid (CSF) from the same patient. ACs are commonly referred to as containing "CSF-like fluid". The objective of this study was to characterize AC fluid by clinical chemistry and to compare AC fluid to CSF drawn from the same patient. Such comparative analysis can shed further light on the mechanisms for filling and sustaining of ACs.Methods: Cyst fluid from 15 adult patients with unilateral temporal AC (9 female, 6 male, age 22-77y) was compared with CSF from the same patients by clinical chemical analysis.Results: AC fluid and CSF had the same osmolarity. There were no significant differences in the concentrations of sodium, potassium, chloride, calcium, magnesium or glucose. We found significant elevated concentration of phosphate in AC fluid (0.39 versus 0.35 mmol/L in CSF; p = 0.02), and significantly reduced concentrations of total protein (0.30 versus 0.41 g/L; p = 0.004), of ferritin (7.8 versus 25.5 ug/L; p = 0.001) and of lactate dehydrogenase (17.9 versus 35.6 U/L; p = 0.002) in AC fluid relative to CSF.Conclusions: AC fluid is not identical to CSF. The differential composition of AC fluid relative to CSF supports secretion or active transport as the mechanism underlying cyst filling. Oncotic pressure gradients or slit-valves as mechanisms for generating fluid in temporal ACs are not supported by these results. © 2010 Berle et al; licensee BioMed Central Ltd.

引用

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