Novel Targets for Treatment of Adult Acute Lymphocytic Leukemia

被引：0
作者：
Margaret T. Kasner
机构：
[1] Thomas Jefferson University,
来源：
Current Hematologic Malignancy Reports | 2010年 / 5卷
关键词：
Acute lymphocytic leukemia; Philadelphia+; Molecular targets; Tyrosine kinase inhibitors; Monoclonal antibodies; mTOR; Notch; CD19; CD20; CD22; CD52; Rapamycin; MEK;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The treatment of acute lymphocytic leukemia (ALL) results in long-term disease-free survival in only 30–40% of adults. Conventional chemotherapy is toxic and woefully ineffective. Therefore, novel agents are being investigated. Among these agents are monoclonal antibodies such as rituximab, epratuzumab, and alemtuzumab and targeted therapies such as tyrosine kinase inhibitors, mTOR inhibitors, and mitogen-activated protein kinase (MEK) inhibitors. This article discusses such novel targets for the treatment of ALL.
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页码：207 / 212
页数：5
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