Liver resistance to toxic effects of CCl4 under conditions of gadolinium chloride depression of Kupffer cells

被引：0
|
作者：
D. D. Cyrendorzhiev
S. N. Kutina
A. A. Zubakhin
机构：
[1] Siberian Division of the Russian Academy of Medical Sciences,Research Center of Clinical and Experimental Medicine
来源：
Bulletin of Experimental Biology and Medicine | 2000年 / 129卷
关键词：
Kupffer cell; tetrachloromethane; liver;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Acute toxic hepatitis was modeled in (CBA×C57B1)F1 mice by single injection of 40% CCl4 in oil. Pretreatment with gadolinium chloride, a selective blocker of Kupffer cells, considerably potentiated damage to hepatocytes leading to generalization of this process, delayed inflammatory infiltration, and inhibited reparative processes. Zymosan administered against the background of gadolinium chloride blockade improved liver resistance to CCl4-induced damage, intensified mononuclear infiltration, and accelerated reparative processes.
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页码：605 / 607
页数：2
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