PS4 - 19. Expression of lipid genes, but not adipokine genes, in visceral adipose tissue is related to liver damage in obese individuals

被引：0

作者：

Marcel Wolfs

Lude Franke

Jingyuan Fu

Bart van de Sluis

Ann Driessen

Sander Rensen

Jan-Willem Greve

Wim Buurman

Timon van Haeften

Ludger Scheja

Ciska Wijmenga

Marten Hofker

机构：

[1] UMC Groningen,Pathology and Medical Biology; Molecular Genetics

[2] University of Groningen,Department of Genetics

[3] UMC Groningen,Nutrition and Toxicology Research Institute Maastricht (NUTRIM)

[4] University of Groningen,Department of Internal Medicine

[5] Maastricht UMC,Department of Biochemistry and Molecular Biology II

[6] UMC Utrecht,undefined

[7] University Medical Center Hamburg,undefined

来源：

Nederlands Tijdschrift voor Diabetologie | 2011年 / 9卷 / 3期

关键词：

Lipid; Adipose Tissue; Lipid Metabolism; Liver Damage; Obese Individual;

D O I：

10.1007/s12467-011-0044-1

中图分类号：

学科分类号：

摘要：

Obesity increases the risk to develop liver steatosis, inflammation, and consequently severe liver damage. This risk is associated with an increased flow of lipids and signaling molecules (adipokines), secreted by adipose tissue, through the liver. However, the relevance of lipids and adipokines in this crosstalk between adipose tissue and liver in obesity-related liver pathology is largely unknown. Therefore we investigated to what extend the expression of genes involved in lipid metabolism and adipokine genes in visceral adipose tissue is correlated to liver pathology in obese individuals.

引用

页码：103 / 103