Hepatitis B and Renal Disease

被引：41
作者：
Chan T.M. [1 ]
机构：
[1] Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, Pokfulam
来源：
Current Hepatitis Reports | 2010年 / 9卷 / 2期
关键词：
Hepatitis B; Kidney transplantation;
D O I：
10.1007/s11901-010-0042-6
中图分类号：
学科分类号：
摘要：
Glomerulonephritis is an important extrahepatic manifestation of chronic hepatitis B virus (HBV) infection. The uncommon occurrence, variability in renal histopathology, and heterogeneity in clinical course present challenges in clinical studies and have resulted in a relative paucity of data and uncertainty with regard to the optimal management of HBV-related glomerular diseases. The advent of nucleos(t)ide analogue medications that effectively suppress HBV replication has markedly altered the clinical outcomes of kidney transplant recipients with HBV infection, but the emergence of drug resistance is an escalating problem. This article reviews the recent knowledge of the pathogenesis and treatment of HBV-related membranous nephropathy, and discusses the management of hepatitis B in kidney transplant recipients, which is continuously evolving. © 2010 The Author(s).
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页码：99 / 105
页数：6
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