Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation

被引:0
作者
Hart S Dengler
Gisele V Baracho
Sidne A Omori
Shane Bruckner
Karen C Arden
Diego H Castrillon
Ronald A DePinho
Robert C Rickert
机构
[1] Program of Inflammatory Disease Research,Department of Pathology
[2] Burnham Institute for Medical Research,undefined
[3] The Ludwig Institute for Cancer Research,undefined
[4] University of California,undefined
[5] San Diego,undefined
[6] La Jolla,undefined
[7] California 92093,undefined
[8] USA.,undefined
[9] The University of Texas Southwestern Medical Center,undefined
[10] Dallas,undefined
[11] Texas 75390,undefined
[12] USA.,undefined
[13] Center for Applied Cancer Science,undefined
[14] Belfer Institute for Innovative Cancer Science,undefined
[15] Dana-Farber Cancer Institute,undefined
来源
Nature Immunology | 2008年 / 9卷
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学科分类号
摘要
Foxo transcription factors are linked to complex regulatory circuits governed by the availability of phosphatidylinositol-3,4,5-trisphosphate. Rickert and colleagues show that Foxo1 has nonredundant functions at many stages of B cell development.
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页码:1388 / 1398
页数:10
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[1]  
Nutt SL(2007)The transcriptional regulation of B cell lineage commitment Immunity 26 715-725
[2]  
Kee BL(1994)Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages Science 265 1573-1577
[3]  
Scott EW(1996)Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation Immunity 5 537-549
[4]  
Simon MC(1994)E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements Cell 79 885-892
[5]  
Anastasi J(1995)Failure of B-cell differentiation in mice lacking the transcription factor EBF Nature 376 263-267
[6]  
Singh H(1994)Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP Cell 79 901-912
[7]  
Wang JH(2004)Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the absence of E2A J. Exp. Med. 199 1689-1700
[8]  
Bain G(2008)Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling Immunity 28 335-345
[9]  
Lin H(2006)IFN regulatory factor 4 and 8 promote Ig light chain κ locus activation in pre-B cell development J. Immunol. 177 7898-7904
[10]  
Grosschedl R(2007)microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells Immunity 27 847-859