Glutamate-induced disturbances in neurotransmission and ionic homeostasis of extracellular Ca2+ and K+ in CA1 hippocampal area

被引：0
|
作者：
V. G. Motin
机构：
[1] Russian Academy of Medical Sciences,P. K. Anokhin institute of Nornal Physiology
来源：
Bulletin of Experimental Biology and Medicine | 1997年 / 124卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The effect of various concentrations ofl-glutamate on neurotransmission in the CA1 hippocampal area was studied using hippocampal slices. Three intervals ofl-glutamate concentration were established: ≤1 mM (all studied parameters are completely reversible upon washout, transmission being preserved), from 1 to 10 mM (both responses to frequency stimulation and single population spikes remain partially suppressed after washout), and above 10 mM (more than 50% suppression of transmission persists after washout).
引用
收藏
页码：844 / 847
页数：3
相关论文
共 50 条
  • [31] Activation of K+ current by BAPTA series Ca2+ chelators introduced into CA1 pyramidal neurones
    Lancaster, B
    Batchelor, AM
    JOURNAL OF PHYSIOLOGY-LONDON, 2000, 523 : 155P - 156P
  • [32] CHANGES IN EXTRACELLULAR [K+] AND [CA2+] INDUCED BY ANOXIA IN NEONATAL RABBIT MEDULLA
    MORRIS, ME
    TRIPPENBACH, T
    AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 264 (04): : R761 - R769
  • [33] EVIDENCE FOR A CA2+-DEPENDENT K+ CONDUCTANCE IN RAT HIPPOCAMPAL CA1 PYRAMIDAL CELL DENDRITES
    ANDREASEN, M
    LAMBERT, JDC
    JOURNAL OF PHYSIOLOGY-LONDON, 1995, 487P : P60 - P61
  • [34] THE K+ DEPENDENCE OF THE AFTERHYPERPOLARIZATION (AHP) IN HIPPOCAMPAL CA1 PYRAMIDAL CELLS
    TANCREDI, V
    FRANK, C
    DICHTER, MA
    PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1987, 408 (03): : S48 - S48
  • [35] CHARACTERIZATION OF CA2+ SIGNALS INDUCED IN HIPPOCAMPAL CA1 NEURONS BY THE SYNAPTIC ACTIVATION OF NMDA RECEPTORS
    ALFORD, S
    FRENGUELLI, BG
    SCHOFIELD, JG
    COLLINGRIDGE, GL
    JOURNAL OF PHYSIOLOGY-LONDON, 1993, 469 : 693 - 716
  • [36] DISTRIBUTION OF GLUTAMATE IN LAYERS OF THE RABBIT HIPPOCAMPAL FIELDS CA1, CA3, AND THE DENTATE AREA
    NITSCH, C
    OKADA, Y
    JOURNAL OF NEUROSCIENCE RESEARCH, 1979, 4 (03) : 161 - 167
  • [37] On the origin of glutamate-induced neuronal Ca2+ overload and mitochondrial depolarization
    Pinelis, V.
    Wabnitz, A.
    Khodorov, B.
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2006, : 510 - 510
  • [38] EFFECTS OF LOWERING [NA+]0 AND [K+]0 AND OF OUABAIN ON QUISQUALATE-INDUCED IONIC CHANGES IN AREA CA1 OF RAT HIPPOCAMPAL SLICES
    STABEL, J
    ARENS, J
    LAMBERT, JDC
    HEINEMANN, U
    NEUROSCIENCE LETTERS, 1990, 110 (1-2) : 60 - 65
  • [39] VARIOUS CA2+ ENTRY BLOCKERS PREVENT GLUTAMATE-INDUCED NEUROTOXICITY
    PIZZI, M
    RIBOLA, M
    VALERIO, A
    MEMO, M
    SPANO, P
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 209 (03) : 169 - 173
  • [40] Does mitochondrial ATp synthase reversal play a crucial role in glutamate-induced deterioration of Ca2+ homeostasis in mature hippocampal cultured neurons?
    Surin, AM
    Storozhevykh, TP
    Vinskaya, NP
    Pinelis, VG
    Duchen, MR
    Khodorov, BI
    BIOLOGICHESKIE MEMBRANY, 2004, 21 (02): : 157 - 159
12345